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B7N269

- ILVC_ECO81

UniProt

B7N269 - ILVC_ECO81

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Escherichia coli O81 (strain ED1a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321UniRule annotation

    GO - Molecular functioni

    1. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciECOL585397:GJCU-4504-MONOMER.
    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:ECED1_4460
    OrganismiEscherichia coli O81 (strain ED1a)
    Taxonomic identifieri585397 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000748: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Ketol-acid reductoisomerasePRO_1000190963Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi585397.ECED1_4460.

    Structurei

    3D structure databases

    ProteinModelPortaliB7N269.
    SMRiB7N269. Positions 3-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000286135.
    KOiK00053.
    OMAiGYEKMVA.
    OrthoDBiEOG625K07.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    IPR014359. KetolA_reductoisomerase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 2 hits.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000116. IlvC_gammaproteo. 1 hit.
    SUPFAMiSSF48179. SSF48179. 2 hits.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7N269-1 [UniParc]FASTAAdd to Basket

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    MANYFNTLNL RQQLAQLGKC RFMGRDEFAD GASYLQGKKV VIVGCGAQGL    50
    NQGLNMRDSG LDISYALRKE AIAEKRASWR KATENGFKVG TYEELIPQAD 100
    LVVNLTPDKQ HSDVVRTVQP LMKDGAALGY SHGFNIVEVG EQIRKDITVV 150
    MVAPKCPGTE VREEYKRGFG VPTLIAVHPE NDPKGEGMAI AKAWAAATGG 200
    HRAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSLLCFDKL VEEGTDPAYA 250
    EKLIQFGWET ITEALKQGGI TLMMDRLSNP AKLRAYALSE QLKEIMAPLF 300
    QKHMDDIISG EFSSGMMADW ANDDKKLLTW REETGKTAFE TAPQYEGKIG 350
    EQEYFDKGVL MIAMVKAGVE LAFETMVDSG IIEESAYYES LHELPLIANT 400
    IARKRLYEMN VVISDTAEYG NYLFSYACVP LLKPFMAELQ PGDLGKAIPE 450
    GAVDNAQLRD VNEAIRSHAI EQVGKKLRGY MTDMKRIAVA G 491
    Length:491
    Mass (Da):54,069
    Last modified:February 10, 2009 - v1
    Checksum:i9AF1AC3EDB6B7E89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928162 Genomic DNA. Translation: CAR10440.1.
    RefSeqiYP_002400266.1. NC_011745.1.

    Genome annotation databases

    EnsemblBacteriaiCAR10440; CAR10440; ECED1_4460.
    GeneIDi7141106.
    KEGGiecq:ECED1_4460.
    PATRICi38492988. VBIEscCol8292_4449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928162 Genomic DNA. Translation: CAR10440.1 .
    RefSeqi YP_002400266.1. NC_011745.1.

    3D structure databases

    ProteinModelPortali B7N269.
    SMRi B7N269. Positions 3-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585397.ECED1_4460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR10440 ; CAR10440 ; ECED1_4460 .
    GeneIDi 7141106.
    KEGGi ecq:ECED1_4460.
    PATRICi 38492988. VBIEscCol8292_4449.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000286135.
    KOi K00053.
    OMAi GYEKMVA.
    OrthoDBi EOG625K07.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .
    BioCyci ECOL585397:GJCU-4504-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    IPR014359. KetolA_reductoisomerase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 2 hits.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000116. IlvC_gammaproteo. 1 hit.
    SUPFAMi SSF48179. SSF48179. 2 hits.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ED1a.

    Entry informationi

    Entry nameiILVC_ECO81
    AccessioniPrimary (citable) accession number: B7N269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3