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B7MZL0 (RPIA_ECO81) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-5-phosphate isomerase A

EC=5.3.1.6
Alternative name(s):
Phosphoriboisomerase A
Short name=PRI
Gene names
Name:rpiA
Ordered Locus Names:ECED1_3372
OrganismEscherichia coli O81 (strain ED1a) [Complete proteome] [HAMAP]
Taxonomic identifier585397 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate By similarity. HAMAP-Rule MF_00170

Catalytic activity

D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP-Rule MF_00170

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP-Rule MF_00170

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00170

Sequence similarities

Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt, non-oxidative branch

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionribose-5-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Ribose-5-phosphate isomerase A HAMAP-Rule MF_00170
PRO_1000194709

Regions

Region28 – 314Substrate binding By similarity
Region81 – 844Substrate binding By similarity
Region94 – 974Substrate binding By similarity

Sites

Active site1031Proton acceptor By similarity
Binding site1211Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B7MZL0 [UniParc].

Last modified April 14, 2009. Version 1.
Checksum: B53C49CC3DB188BC

FASTA21922,860
        10         20         30         40         50         60 
MTQDELKKAV GWAALQYVQP GTIVGVGTGS TAAHFIDALG TMKGQIEGAV SSSDASTEKL 

        70         80         90        100        110        120 
KSLGIHVFDL NEVDSLGIYV DGADEINGHM QMIKGGGAAL TREKIIASVA EKFICIADAS 

       130        140        150        160        170        180 
KQVDILGKFP LPVEVIPMAR SAVARQLVKL GGRPEYRQGV VTDNGNVILD VHGMEILDPI 

       190        200        210 
AMENAINAIP GVVTVGLFAN RGADVALIGT PDGVKTIVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928162 Genomic DNA. Translation: CAR09528.2.
RefSeqYP_002399249.1. NC_011745.1.

3D structure databases

ProteinModelPortalB7MZL0.
SMRB7MZL0. Positions 2-219.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING585397.ECED1_3372.

Proteomic databases

PRIDEB7MZL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR09528; CAR09528; ECED1_3372.
GeneID7141397.
KEGGecq:ECED1_3372.
PATRIC38490800. VBIEscCol8292_3375.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0120.
HOGENOMHOG000276368.
KOK01807.
OMAGACHVQE.
OrthoDBEOG67MF61.
ProtClustDBPRK00702.

Enzyme and pathway databases

BioCycECOL585397:GJCU-3417-MONOMER.
UniPathwayUPA00115; UER00412.

Family and domain databases

HAMAPMF_00170. Rib_5P_isom_A.
InterProIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERPTHR11934. PTHR11934. 1 hit.
PfamPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsTIGR00021. rpiA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRPIA_ECO81
AccessionPrimary (citable) accession number: B7MZL0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 14, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways