B7MY25 (SDHD_ECO81) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-serine dehydratase
EC=4.3.1.18

Alternative name(s):
D-serine deaminase
Short name=DSD

Gene names

Name:	dsdA
Ordered Locus Names:	ECED1_2813

Organism

Escherichia coli O81 (strain ED1a) [Complete proteome] [HAMAP]

Taxonomic identifier

585397 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP-Rule MF_01030
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01030
Subunit structure	Monomer By similarity. HAMAP-Rule MF_01030
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	D-serine dehydratase HAMAP-Rule MF_01030		PRO_1000149388
Amino acid modifications
	Modified residue	118	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7MY25 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 19AEB9B1CA573271	FASTA	442	47,837
	10 20 30 40 50 60 MENAKMNSLI AQYPLVEDLV ALKETTWFNP GTTSLAEGLP YVGLTEQDVQ DAHARLSRFA 70 80 90 100 110 120 PYLAKAFPET AAAGGIIESE LVAIPAMQKR LEKEYQQPIS GQLLLKKDSH LPISGSIKAR 130 140 150 160 170 180 GGIYEVLAHA EKLALEAGLL TLEDDYSKLL SPEFKQFFSQ YSIAVGSTGN LGLSIGIMSA 190 200 210 220 230 240 RIGFKVTVHM SADARAWKKA KLRSHGVTVV EYEQDYGVAV EEGRKAAQSD PNCFFIDDEN 250 260 270 280 290 300 SRTLFLGYSV AGQRLKAQFA QQGRIVDADN PLFVYLPCGV GGGPGGVAFG LKLAFGDHVH 310 320 330 340 350 360 CFFAEPTHSP CMLLGVHTGL HDQISVQDIG IDNLTAADGL AVGRASGFVG RAMERLLDGF 370 380 390 400 410 420 YTLSDQTMYD MLGWLAQEEG IRLEPSALAG MAGPQRVCAS VSYQQLHGFS AEQLRNATHL 430 440 VWATGGGMVP EEEMNQYLAK GR

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ED1a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU928162 Genomic DNA. Translation: CAR08991.2.
RefSeq	YP_002398721.1. NC_011745.1.
3D structure databases
ProteinModelPortal	B7MY25.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR08991; CAR08991; ECED1_2813.
GeneID	7140527.
KEGG	ecq:ECED1_2813.
PATRIC	38489650. VBIEscCol8292_2818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3048.
HOGENOM	HOG000218072.
KO	K01753.
OMA	HCLFAEP.
ProtClustDB	PRK02991.
Enzyme and pathway databases
BioCyc	ECOL585397:GJCU-2845-MONOMER.
Family and domain databases
HAMAP	MF_01030. D-Ser_dehydrat.
InterPro	IPR011780. D_Ser_am_lyase. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
PANTHER	PTHR10314:SF9. PTHR10314:SF9. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD_ECO81

Accession

Primary (citable) accession number: B7MY25

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program