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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Escherichia coli O81 (strain ED1a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn(2+) or Co2+ ions per subunit.UniRule annotation
  • glutathioneUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Cobalt or zinc 1UniRule annotation
Active sitei82 – 821UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 1UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 2UniRule annotation
Active sitei144 – 1441UniRule annotation
Metal bindingi145 – 1451Cobalt or zinc 2UniRule annotation
Metal bindingi169 – 1691Cobalt or zinc 1UniRule annotation
Metal bindingi355 – 3551Cobalt or zinc 2UniRule annotation

GO - Molecular functioni

  1. acetylornithine deacetylase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL585397:GJCU-4705-MONOMER.
UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
Ordered Locus Names:ECED1_4662
OrganismiEscherichia coli O81 (strain ED1a)
Taxonomic identifieri585397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000748: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Acetylornithine deacetylasePRO_1000163955Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi585397.ECED1_4662.

Structurei

3D structure databases

ProteinModelPortaliB7MR48.
SMRiB7MR48. Positions 2-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000243769.
KOiK01438.
OMAiAANRICG.
OrthoDBiEOG60651W.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7MR48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASCGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLAKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHILQLR DNLKERYHYD AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH
Length:383
Mass (Da):42,266
Last modified:March 24, 2009 - v1
Checksum:iDDD84477F025524E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928162 Genomic DNA. Translation: CAR10632.1.
RefSeqiYP_002400455.1. NC_011745.1.

Genome annotation databases

EnsemblBacteriaiCAR10632; CAR10632; ECED1_4662.
GeneIDi7139096.
KEGGiecq:ECED1_4662.
PATRICi38493414. VBIEscCol8292_4653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928162 Genomic DNA. Translation: CAR10632.1.
RefSeqiYP_002400455.1. NC_011745.1.

3D structure databases

ProteinModelPortaliB7MR48.
SMRiB7MR48. Positions 2-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi585397.ECED1_4662.

Protein family/group databases

MEROPSiM20.974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR10632; CAR10632; ECED1_4662.
GeneIDi7139096.
KEGGiecq:ECED1_4662.
PATRICi38493414. VBIEscCol8292_4653.

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000243769.
KOiK01438.
OMAiAANRICG.
OrthoDBiEOG60651W.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.
BioCyciECOL585397:GJCU-4705-MONOMER.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ED1a.

Entry informationi

Entry nameiARGE_ECO81
AccessioniPrimary (citable) accession number: B7MR48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.