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B7MR48

- ARGE_ECO81

UniProt

B7MR48 - ARGE_ECO81

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Protein
Acetylornithine deacetylase
Gene
argE, ECED1_4662
Organism
Escherichia coli O81 (strain ED1a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Binds 2 zinc or cobalt ions per subunit By similarity.UniRule annotation
Glutathione By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Cobalt or zinc 1 By similarity
Active sitei82 – 821 By similarity
Metal bindingi112 – 1121Cobalt or zinc 1 By similarity
Metal bindingi112 – 1121Cobalt or zinc 2 By similarity
Active sitei144 – 1441 By similarity
Metal bindingi145 – 1451Cobalt or zinc 2 By similarity
Metal bindingi169 – 1691Cobalt or zinc 1 By similarity
Metal bindingi355 – 3551Cobalt or zinc 2 By similarity

GO - Molecular functioni

  1. acetylornithine deacetylase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL585397:GJCU-4705-MONOMER.
UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:ECED1_4662
OrganismiEscherichia coli O81 (strain ED1a)
Taxonomic identifieri585397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000748: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Acetylornithine deacetylaseUniRule annotation
PRO_1000163955Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi585397.ECED1_4662.

Structurei

3D structure databases

ProteinModelPortaliB7MR48.
SMRiB7MR48. Positions 2-381.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000243769.
KOiK01438.
OMAiCETQQIA.
OrthoDBiEOG60651W.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7MR48-1 [UniParc]FASTAAdd to Basket

« Hide

MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV    50
EVQPVPGTRN KFNMLASCGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE 100
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLAKPLYILA TADEETSMAG 150
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA 200
RGVNAIELMH DAIGHILQLR DNLKERYHYD AFTVPYPTLN LGHIHGGDAS 250
NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP 300
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS 350
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH 383
Length:383
Mass (Da):42,266
Last modified:March 24, 2009 - v1
Checksum:iDDD84477F025524E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928162 Genomic DNA. Translation: CAR10632.1.
RefSeqiYP_002400455.1. NC_011745.1.

Genome annotation databases

EnsemblBacteriaiCAR10632; CAR10632; ECED1_4662.
GeneIDi7139096.
KEGGiecq:ECED1_4662.
PATRICi38493414. VBIEscCol8292_4653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928162 Genomic DNA. Translation: CAR10632.1 .
RefSeqi YP_002400455.1. NC_011745.1.

3D structure databases

ProteinModelPortali B7MR48.
SMRi B7MR48. Positions 2-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585397.ECED1_4662.

Protein family/group databases

MEROPSi M20.974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR10632 ; CAR10632 ; ECED1_4662 .
GeneIDi 7139096.
KEGGi ecq:ECED1_4662.
PATRICi 38493414. VBIEscCol8292_4653.

Phylogenomic databases

eggNOGi COG0624.
HOGENOMi HOG000243769.
KOi K01438.
OMAi CETQQIA.
OrthoDBi EOG60651W.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00110 .
BioCyci ECOL585397:GJCU-4705-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_01108. ArgE.
InterProi IPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ED1a.

Entry informationi

Entry nameiARGE_ECO81
AccessioniPrimary (citable) accession number: B7MR48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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