B7MQA5 (B7MQA5_ECO81) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase HAMAP MF_01671
EC=1.1.1.18 HAMAP MF_01671

Alternative name(s):
Myo-inositol 2-dehydrogenase HAMAP MF_01671

Gene names

Name:	iolG HAMAP MF_01671 EMBL CAR06517.1
Ordered Locus Names:	ECED1_0304

Organism

Escherichia coli O81 (strain ED1a) [Complete proteome] [HAMAP]

Taxonomic identifier

585397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 SAAS SAAS000683
Subunit structure	Homotetramer By similarity. SAAS SAAS000683 HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family. HAMAP MF_01671

Ontologies

Keywords
Ligand	NAD SAAS SAAS000683 HAMAP MF_01671
Molecular function	Oxidoreductase SAAS SAAS000683 HAMAP MF_01671 EMBL CAR06517.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7MQA5 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 70FF325634201501	FASTA	342	38,081
	10 20 30 40 50 60 MKRKQKMTLK AGIVGIGMIG SDHLRRLANT VSGVEVVAVC DIVAGRAQAA LDKYAIEAKD 70 80 90 100 110 120 YNDYHDLIND KDVEVVIITA SNEAHADVAV AALNANKYVF CEKPLAVTAA DCQRVIEAEQ 130 140 150 160 170 180 KNGKRMVQIG FMRRYDKGYV QLKNIIDSGE IGQPLMVHGR HYNASTVPEY KTPQAIYETL 190 200 210 220 230 240 IHEIDIMHWL LNEDYKTVKV YFPRQSSLVT TLRDPQLVVM ETTSGINIVV EVFVNCQYGY 250 260 270 280 290 300 DIHCDVTGEK GMAELPTVAS AAVRKAAKYS TDILVDWKQR FIDAYDIEFQ DFFDRLNAGL 310 320 330 340 PPAGPTSWDG YLAAVTADAC VKSQETGNTE IVELPSKPDF YK

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed: 19165319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU928162 Genomic DNA. Translation: CAR06517.1.
RefSeq	YP_002396366.1. NC_011745.1.
3D structure databases
ProteinModelPortal	B7MQA5.
ModBase	Search...
Protein-protein interaction databases
STRING	B7MQA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000146351; EBESCP00000132546; EBESCG00000145287.
GeneID	7142445.
GenomeReviews	Gene locus ECED1_0304 in contig CU928162_GR.
PATRIC	38484520. VBIEscCol8292_0295.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009259.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK894854.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7MQA5_ECO81

Accession

Primary (citable) accession number: B7MQA5

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)