ID   B7MMZ8_ECO45            Unreviewed;       104 AA.
AC   B7MMZ8;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit {ECO:0000313|EMBL:CAR02926.1};
GN   OrderedLocusNames=ECS88_1611 {ECO:0000313|EMBL:CAR02926.1};
OS   Escherichia coli O45:K1 (strain S88 / ExPEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585035 {ECO:0000313|EMBL:CAR02926.1, ECO:0000313|Proteomes:UP000000747};
RN   [1] {ECO:0000313|Proteomes:UP000000747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S88 / ExPEC {ECO:0000313|Proteomes:UP000000747};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000699-2};
CC       Note=Binds 1 Mg(2+) ion per trimer. {ECO:0000256|PIRSR:PIRSR000699-2};
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DR   EMBL; CU928161; CAR02926.1; -; Genomic_DNA.
DR   AlphaFoldDB; B7MMZ8; -.
DR   SMR; B7MMZ8; -.
DR   KEGG; ecz:ECS88_1611; -.
DR   HOGENOM; CLU_152490_1_0_6; -.
DR   Proteomes; UP000000747; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   CDD; cd00215; PTS_IIA_lac; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR003188; PTS_IIA_lac/cel.
DR   InterPro; IPR036542; PTS_IIA_lac/cel_sf.
DR   PANTHER; PTHR34382; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIA COMPONENT; 1.
DR   PANTHER; PTHR34382:SF7; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIA COMPONENT; 1.
DR   Pfam; PF02255; PTS_IIA; 1.
DR   PIRSF; PIRSF000699; PTS_IILac_III; 1.
DR   SUPFAM; SSF46973; Enzyme IIa from lactose specific PTS, IIa-lac; 1.
DR   PROSITE; PS51095; PTS_EIIA_TYPE_3; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|PIRSR:PIRSR000699-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000699-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000747};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   ACT_SITE        77
FT                   /note="Tele-phosphohistidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000699-1"
FT   BINDING         80
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="ligand shared between all trimeric partners"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000699-2"
FT   MOD_RES         77
FT                   /note="Phosphohistidine; by HPr"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00418"
SQ   SEQUENCE   104 AA;  11462 MW;  1F5051ACE8C7EB11 CRC64;
     MMFADEELVM ELLINAGQAR SDAMEAIRCA GQKDWQGATK LMASSESACL QAHKIQTALI
     SQDEGCGKIE VNLILIHAQD HLMNAILCQD LAREIISLRK ELHA
//