B7MMY5 (UXAB_ECO45) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altronate oxidoreductase
EC=1.1.1.58

Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase

Gene names

Name:	uxaB
Ordered Locus Names:	ECS88_1598

Organism

Escherichia coli O45:K1 (strain S88 / ExPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

585035 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase HAMAP-Rule MF_00670		PRO_1000131506
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7MMY5 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 4EA4766DF35BC2FD	FASTA	483	54,834
	10 20 30 40 50 60 MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV VRPIETSFPP 70 80 90 100 110 120 SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS EYDEFLKLAH NPEMRFVFSN 130 140 150 160 170 180 TTEAGISYHA GDKFDDAPAV SYPAKLTRLL FERFSHFNGA LDKGWIIIPC ELIDYNGDAL 190 200 210 220 230 240 RELVLRYAQE WALPEAFIQW LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT 250 260 270 280 290 300 AEHFYLFVIQ GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 310 320 330 340 350 360 LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP YIKHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY RGERNGETYP VQDDAHWLER 430 440 450 460 470 480 YQQLWSQYRD RVIGTQELVA IVLAEKDHWE QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S88 / ExPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU928161 Genomic DNA. Translation: CAR02913.1.
RefSeq	YP_002391337.1. NC_011742.1.
3D structure databases
ProteinModelPortal	B7MMY5.
SMR	B7MMY5. Positions 2-482.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR02913; CAR02913; ECS88_1598.
GeneID	7133598.
KEGG	ecz:ECS88_1598.
PATRIC	18410909. VBIEscCol91599_1589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HOG000029586.
KO	K00041.
OMA	HNTFCST.
ProtClustDB	PRK03643.
Enzyme and pathway databases
BioCyc	ECOL585035:GJWP-1599-MONOMER.
UniPathway	UPA00246.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
HAMAP	MF_00670. Altron_oxidoreduct.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR023668. Altronate_OxRdtase. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXAB_ECO45

Accession

Primary (citable) accession number: B7MMY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 29, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program