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Protein

Adenine deaminase

Gene

ade

Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciECOL585035:GJWP-4075-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
AdenaseUniRule annotation
Short name:
Adenine aminaseUniRule annotation
Gene namesi
Name:adeUniRule annotation
Ordered Locus Names:ECS88_4090
OrganismiEscherichia coli O45:K1 (strain S88 / ExPEC)
Taxonomic identifieri585035 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000747 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Adenine deaminasePRO_1000146232Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7MFN5.
SMRiB7MFN5. Positions 29-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenine deaminase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276949.
KOiK01486.
OMAiCTDDKHL.
OrthoDBiEOG622PNM.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01518. Adenine_deamin.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01178. ade. 1 hit.

Sequencei

Sequence statusi: Complete.

B7MFN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSINHKFH HISRTEYQEL LAVSRGDAVA DYIIDNVSIL DLINGGEISG
60 70 80 90 100
PIVIKGRYIA GVGAEYADAP ALQRIDARGA TAVPGFIDAH LHIESSMMTP
110 120 130 140 150
VTFETATLPR GLTTVICDPH EIVNVMGEAG FAWFARCAEQ ARQNQYLQVS
160 170 180 190 200
SCVPALEGCD VNGASFTLEQ MLAWRDHPQV TGLAEMMDYP GVISGQNALL
210 220 230 240 250
DKLDAFRHLT LDGHCPGLGG KELNAYIAAG IENCHESYQL EEGRRKLQLG
260 270 280 290 300
MSLMIREGSA ARNLNALAPL INEFNSPQCM LCTDDRNPWE IAHEGHIDAL
310 320 330 340 350
IRRLIEQHNV PLHVAYRVAS WSTARHFGLN HLGLLAPGKQ ADIVLLSDAR
360 370 380 390 400
KVTVQQVLVK GEPIDAQTLQ AEESARLAQS APPYGNTIDR QPVSASDFAL
410 420 430 440 450
QFTPGKRYRV IEVIHNELIT HSRSSVYSEN GFDRDDVCFI AVLERYGQRL
460 470 480 490 500
APACGLLGGF GLNEGALAAT VSHDSHNIVV IGRSAEEMAL AVNQVIQDGG
510 520 530 540 550
GLCVVRNGQV QSHLPLPIAG LMSTDTAQSL AEQIDALKAA ARECGPLPDE
560 570 580
PFIQMAFLSL PVIPALKLTS QGLFDGEKFA FTTLEFTE
Length:588
Mass (Da):63,851
Last modified:February 10, 2009 - v1
Checksum:iEF00812CDD92F402
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928161 Genomic DNA. Translation: CAR05297.1.

Genome annotation databases

EnsemblBacteriaiCAR05297; CAR05297; ECS88_4090.
KEGGiecz:ECS88_4090.
PATRICi18415861. VBIEscCol91599_4019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928161 Genomic DNA. Translation: CAR05297.1.

3D structure databases

ProteinModelPortaliB7MFN5.
SMRiB7MFN5. Positions 29-132.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR05297; CAR05297; ECS88_4090.
KEGGiecz:ECS88_4090.
PATRICi18415861. VBIEscCol91599_4019.

Phylogenomic databases

HOGENOMiHOG000276949.
KOiK01486.
OMAiCTDDKHL.
OrthoDBiEOG622PNM.

Enzyme and pathway databases

BioCyciECOL585035:GJWP-4075-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01518. Adenine_deamin.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01178. ade. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S88 / ExPEC.

Entry informationi

Entry nameiADEC_ECO45
AccessioniPrimary (citable) accession number: B7MFN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.