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B7MER5 (SYGA_ECO45) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine--tRNA ligase alpha subunit

EC=6.1.1.14
Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS
Gene names
Name:glyQ
Ordered Locus Names:ECS88_3977
OrganismEscherichia coli O45:K1 (strain S88 / ExPEC) [Complete proteome] [HAMAP]
Taxonomic identifier585035 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP-Rule MF_00254

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00254.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Glycine--tRNA ligase alpha subunit HAMAP-Rule MF_00254
PRO_1000197192

Sequences

Sequence LengthMass (Da)Tools
B7MER5 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 8C22062079FD4DDA

FASTA30334,716
        10         20         30         40         50         60 
MQKFDTRTFQ GLILTLQDYW ARQGCTIVQP LDMEVGAGTS HPMTCLRALG PEPMAAAYVQ 

        70         80         90        100        110        120 
PSRRPTDGRY GENPNRLQHY YQFQVVIKPS PDNIQELYLG SLKELGMDPT IHDIRFVEDN 

       130        140        150        160        170        180 
WENPTLGAWG LGWEVWLNGM EVTQFTYFQQ VGGLECKPVT GEITYGLERL AMYIQGVDSV 

       190        200        210        220        230        240 
YDLVWSDGPL GKTTYGDVFH QNEVEQSTYN FEYADVDFLF TCFEQYEKEA QQLLALENPL 

       250        260        270        280        290        300 
PLPAYERILK AAHSFNLLDA RKAISVTERQ RYILRIRTLT KAVAEAYYAS REALGFPMCN 


KDK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928161 Genomic DNA. Translation: CAR05186.1.
RefSeqYP_002393548.1. NC_011742.1.

3D structure databases

ProteinModelPortalB7MER5.
SMRB7MER5. Positions 9-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING585035.ECS88_3977.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR05186; CAR05186; ECS88_3977.
GeneID7130043.
KEGGecz:ECS88_3977.
PATRIC18415632. VBIEscCol91599_3906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0752.
HOGENOMHOG000264291.
KOK01878.
OMACVILQPY.
OrthoDBEOG661H9S.
ProtClustDBPRK09348.

Enzyme and pathway databases

BioCycECOL585035:GJWP-3963-MONOMER.

Family and domain databases

HAMAPMF_00254. Gly_tRNA_synth_alpha.
InterProIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSPR01044. TRNASYNTHGA.
TIGRFAMsTIGR00388. glyQ. 1 hit.
PROSITEPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYGA_ECO45
AccessionPrimary (citable) accession number: B7MER5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries