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B7MCD1 (BETB_ECO45) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:ECS88_0320
OrganismEscherichia coli O45:K1 (strain S88 / ExPEC) [Complete proteome] [HAMAP]
Taxonomic identifier585035 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_1000133946

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
B7MCD1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: D48C604083472FDE

FASTA49052,913
        10         20         30         40         50         60 
MSRMAEQQLY IHGGYTSATS GRTFETINPA NGNVLATVQA AGREDVDRAV KSAQQGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVDILR ERNDELAKLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLI 

       130        140        150        160        170        180 
PALEGSQIPL RETSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IYSEAGLPDG VFNVLPGVGA ETGQYLTDHP GIAKVSFTGG VASGKKVMAN 

       250        260        270        280        290        300 
SAASSLKEVT MELGGKSPLI VFDDADLDLA ADITMMANFF SSGQVCTNGT RVFVPTKCKA 

       310        320        330        340        350        360 
AFEQKILARV ERIRAGDVFD PQTNFGPLVS FPHRDNVLRY IAKGIEEGAR VLCGGDVLKG 

       370        380        390        400        410        420 
DSFDNGAWVA PTVFTDCSDD MTIVREEIFG PVMSILTYES EDEVIRRAND TDYGLAAGIV 

       430        440        450        460        470        480 
TADLNLAHRV IHQLEAGICW INTWGESPAE MPVGGYKHSG IGRENGVMTL QSYTQVKSIQ 

       490 
VEMAKFQSIF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU928161 Genomic DNA. Translation: CAR01671.1.
RefSeqYP_002390150.1. NC_011742.1.

3D structure databases

ProteinModelPortalB7MCD1.
SMRB7MCD1. Positions 2-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7MCD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000137100; EBESCP00000127696; EBESCG00000137181.
GeneID7130002.
GenomeReviewsGene locus ECS88_0320 in contig CU928161_GR.
PATRIC18408302. VBIEscCol91599_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009175.
HOGENOMHBG752218.
OMAGRENGLM.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycECOL585035:ECS88_0320-MONOMER.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_ECO45
AccessionPrimary (citable) accession number: B7MCD1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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