Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-carnitine CoA-transferase

Gene

caiB

Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.UniRule annotation

Catalytic activityi

(E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA.UniRule annotation
4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97Coenzyme AUniRule annotation1
Binding sitei104Coenzyme AUniRule annotation1
Active sitei169NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
L-carnitine CoA-transferaseUniRule annotation (EC:2.8.3.21UniRule annotation)
Alternative name(s):
Crotonobetainyl-CoA:carnitine CoA-transferaseUniRule annotation
Gene namesi
Name:caiBUniRule annotation
Ordered Locus Names:ECS88_0041
OrganismiEscherichia coli O45:K1 (strain S88 / ExPEC)
Taxonomic identifieri585035 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000747 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001362451 – 405L-carnitine CoA-transferaseAdd BLAST405

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7MAG1
SMRiB7MAG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CaiB/BaiF CoA-transferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219745
KOiK08298
OMAiSGFRYIN

Family and domain databases

Gene3Di3.40.50.10540, 2 hits
HAMAPiMF_01050 CaiB, 1 hit
InterProiView protein in InterPro
IPR023452 CoA-Trfase_CaiB
IPR003673 CoA-Trfase_fam_III
IPR023606 CoA-Trfase_III_dom_sf
PANTHERiPTHR43949 PTHR43949, 1 hit
PfamiView protein in Pfam
PF02515 CoA_transf_3, 1 hit
SUPFAMiSSF89796 SSF89796, 1 hit

Sequencei

Sequence statusi: Complete.

B7MAG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHLPMPKFG PLAGLRVVFS GIEIAGPFAG QMFAEWGAEV IWIENVAWAD
60 70 80 90 100
TIRVQPNYPQ LSRRNLHALS LNIFKDEGRE AFLKLMETTD IFIEASKGPA
110 120 130 140 150
FARRGITDEV LWQHNPKLVI AHLSGFGQYG TEEYTNLPAY NTIAQAFSGY
160 170 180 190 200
LIQNGDVDQP MPAFPYTADY FSGLTATTAA LAALHKVRET GKGESIDIAM
210 220 230 240 250
YEVMLRMGQY FMMDYFNGGE MCPRMTKGKD PYYAGCGLYK CADGYIVMEL
260 270 280 290 300
VGITQIAECF KDIGLAHLLG TPEIPEGTQL IHRIECPYGP LVEEKLDAWL
310 320 330 340 350
AAHTIAEVKE RFAELNIACA KVLTVPELES NPQYVARESI TQWQTMDGRT
360 370 380 390 400
CKGPNIMPKF KNNPGQIWRG MPSHGMDTAA ILKNIGYSEN DIQELVSKGL

AKVED
Length:405
Mass (Da):45,053
Last modified:February 10, 2009 - v1
Checksum:i275835C6A38B62F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928161 Genomic DNA Translation: CAR01407.1
RefSeqiWP_000349942.1, NC_011742.1

Genome annotation databases

EnsemblBacteriaiCAR01407; CAR01407; ECS88_0041
KEGGiecz:ECS88_0041

Similar proteinsi

Entry informationi

Entry nameiCAIB_ECO45
AccessioniPrimary (citable) accession number: B7MAG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health