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Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 174NADUniRule annotation7
Nucleotide bindingi224 – 225NADUniRule annotation2
Nucleotide bindingi304 – 306NADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
Short name:
2,3-DKG reductaseUniRule annotation
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
Gene namesi
Name:dlgDUniRule annotation
Ordered Locus Names:EFER_3573
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000745 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001343441 – 3322,3-diketo-L-gulonate reductaseAdd BLAST332

Proteomic databases

PRIDEiB7LTI6

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7LTI6
SMRiB7LTI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249660
KOiK08092
OMAiDILCGVM
OrthoDBiPOG091H0T0F

Family and domain databases

HAMAPiMF_00820 Diketo_gul_reduc, 1 hit
InterProiView protein in InterPro
IPR023689 Diketo_gul_Rdtase
IPR036111 Mal/L-sulfo/L-lacto_DH-like_sf
IPR003767 Malate/L-lactate_DH-like
PANTHERiPTHR11091 PTHR11091, 1 hit
PfamiView protein in Pfam
PF02615 Ldh_2, 1 hit
SUPFAMiSSF89733 SSF89733, 1 hit

Sequencei

Sequence statusi: Complete.

B7LTI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSFEQLKA AFNRVLLSRG VAVETADACA EMFARTTESG VYSHGVNRFP
60 70 80 90 100
RFIQQLDNGD IIPDAEAKRI TTLGAIEQWD AQRSIGNLTA KKMMDRAIEL
110 120 130 140 150
AADHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK
160 170 180 190 200
ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RQLPVDGGFD
210 220 230 240 250
DEGNLTKEPG VIEKNRRILP MGYWKGSGMS IVLDMIATLL SDGASVAEVT
260 270 280 290 300
QDNSDEYGVS QIFIAIEVDK LIDGPTRDAK LQRIMDYVTT AERADENQAI
310 320 330
RLPGHEFTTL LAENRRNGIT VDDSVWAKIQ AL
Length:332
Mass (Da):36,502
Last modified:February 10, 2009 - v1
Checksum:i2FE33F0399475804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA Translation: CAQ91045.1
RefSeqiWP_000868495.1, NC_011740.1

Genome annotation databases

EnsemblBacteriaiCAQ91045; CAQ91045; EFER_3573
KEGGiefe:EFER_3573

Similar proteinsi

Entry informationi

Entry nameiDLGD_ESCF3
AccessioniPrimary (citable) accession number: B7LTI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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