Reviewed, UniProtKB/Swiss-Prot B7LTH9 (XYLA_ESCF3)

Names and origin

Protein names

Recommended name:
    Xylose isomerase
    EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	EFER_3566

Organism

Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) [Complete proteome] [HAMAP]

Taxonomic identifier

585054 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Xylose isomerase HAMAP MF_00455		PRO_1000200298
Sites
	Active site	101	1	By similarity
	Active site	104	1	By similarity
	Metal binding	232	1	Magnesium 1 By similarity
	Metal binding	268	1	Magnesium 1 By similarity
	Metal binding	268	1	Magnesium 2 By similarity
	Metal binding	271	1	Magnesium 2 By similarity
	Metal binding	296	1	Magnesium 1 By similarity
	Metal binding	307	1	Magnesium 2 By similarity
	Metal binding	309	1	Magnesium 2 By similarity
	Metal binding	339	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7LTH9-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: A6AB4EB1E6E0963B	FASTA	440	49,742
	10 20 30 40 50 60 MQAYFDQLDR VRYEGPKTTN PLAFRHYNPD ELVLGKRMED HLRFAACYWH TFCWNGADMF 70 80 90 100 110 120 GVGAFDRPWQ QPGEALMLAK RKADVAFEFF HKLNVPFYCF HDVDVSPEGA SLKEYKNNFA 130 140 150 160 170 180 EMVDVLAAKQ EQSGVKLLWG TANCFTNPRY GAGAATNPDP EVFSWAATQV VTAMEATKRL 190 200 210 220 230 240 GGENYVLWGG REGYETLLNT DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK 250 260 270 280 290 300 HQYDYDAATV YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG 310 320 330 340 350 360 DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY DLFYGHIGAM 370 380 390 400 410 420 DTMALALKVA ARMIEDGELD KRVAQRYSGW NSELGQQILK GQMSLSDLAK YAQDHNLSPV 430 440 HQSGHQELLE SLVNHYLFDK

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed: 19165319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU928158 Genomic DNA. Translation: CAQ91038.1.
RefSeq	YP_002384641.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7122389.
GenomeReviews	Gene locus EFER_3566 in contig CU928158_GR.
KEGG	efe:EFER_3566.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_ESCF3

Accession

Primary (citable) accession number: B7LTH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)