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Protein

Thymidine kinase

Gene

tdk

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Proton acceptorUniRule annotation1
Metal bindingi156ZincUniRule annotation1
Metal bindingi158ZincUniRule annotation1
Metal bindingi193ZincUniRule annotation1
Metal bindingi196ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27ATPUniRule annotation8
Nucleotide bindingi98 – 101ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:EFER_1717Imported
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)Imported
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000745 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7LSE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

B7LSE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYITWVRVLS PMAQLYFYYS AMNAGKSTAL LQSSYNYQER GMRTVVYTAE
60 70 80 90 100
IDDRFGAGKV SSRIGLSSPA RLFNQNSSLF EEIRAENAKQ PVDCVLVDEC
110 120 130 140 150
QFLTRQQVYD LSEVVDQLDI PVLCYGLRTD FRGELFGGSQ YLLAWSDKLV
160 170 180 190 200
ELKTICFCGR KASMVLRLDQ EGRPYNEGEQ VVIGGNERYV SVCRKHYKEA
210
LATDSLVAIQ KRHRQAE
Length:217
Mass (Da):24,760
Last modified:February 10, 2009 - v1
Checksum:iE5D28506843F490D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA Translation: CAQ89233.1

Genome annotation databases

EnsemblBacteriaiCAQ89233; CAQ89233; EFER_1717
KEGGiefe:EFER_1717

Similar proteinsi

Entry informationi

Entry nameiB7LSE7_ESCF3
AccessioniPrimary (citable) accession number: B7LSE7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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