Reviewed, UniProtKB/Swiss-Prot B7LQ21 (MSRB_ESCF3)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	EFER_1294

Organism

Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) [Complete proteome] [HAMAP]

Taxonomic identifier

585054 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_1000145373
Sites
	Active site	118	1	Nucleophile By similarity
	Metal binding	46	1	Zinc By similarity
	Metal binding	49	1	Zinc By similarity
	Metal binding	95	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7LQ21-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 40CAA89B27E98C74	FASTA	137	15,463
	10 20 30 40 50 60 MANKPSVDDL KENLSEMQFY VTQKHGTEPP YTGRLLHNKR DGVYRCLVCD TPLFNSQSKY 70 80 90 100 110 120 DSGCGWPSFY EPVNENSIRY LTDLSHGMER IEIRCGHCDA HLGHVFPDGP QPTGERYCVN 130 SASLSFTDEK SGDQIKG

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed: 19165319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU928158 Genomic DNA. Translation: CAQ88818.1.
RefSeq	YP_002382451.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7120173.
GenomeReviews	Gene locus EFER_1294 in contig CU928158_GR.
KEGG	efe:EFER_1294.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01400. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_ESCF3

Accession

Primary (citable) accession number: B7LQ21

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	October 13, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)