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B7LPQ4

- NAGK_ESCF3

UniProt

B7LPQ4 - NAGK_ESCF3

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciEFER585054:GJJM-1277-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:EFER_1283
    OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
    Taxonomic identifieri585054 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000745: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_1000140189Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi585054.EFER_1283.

    Structurei

    3D structure databases

    ProteinModelPortaliB7LPQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OMAiMESINES.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7LPQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDIGGT KIALGVFDSG RQLQWEKRVP TPRDSYDAFL DAVCELVAEA    50
    DQRFGCKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
    RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLIF NGKPITGKSY 150
    ITGEFGHMRL PVDALTMMGL DFPLRRCGCG QIGCIENYLS GRGFAWLWQH 200
    YYHQPLQAPE IIALWEEGDE RAQAHVDRYL DLLAVCLGNI LTIVDPDLVV 250
    IGGGLSNFTA ITTQLADRLP RHLLPVARVP RIERARHGDA GGMRGAAFLH 300
    LSD 303
    Length:303
    Mass (Da):33,056
    Last modified:February 10, 2009 - v1
    Checksum:i1394E3FA654ECAB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928158 Genomic DNA. Translation: CAQ88807.1.
    RefSeqiYP_002382440.1. NC_011740.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ88807; CAQ88807; EFER_1283.
    GeneIDi7120847.
    KEGGiefe:EFER_1283.
    PATRICi32126959. VBIEscFer122920_1236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928158 Genomic DNA. Translation: CAQ88807.1 .
    RefSeqi YP_002382440.1. NC_011740.1.

    3D structure databases

    ProteinModelPortali B7LPQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585054.EFER_1283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ88807 ; CAQ88807 ; EFER_1283 .
    GeneIDi 7120847.
    KEGGi efe:EFER_1283.
    PATRICi 32126959. VBIEscFer122920_1236.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OMAi MESINES.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci EFER585054:GJJM-1277-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35469 / DSM 13698 / CDC 0568-73.

    Entry informationi

    Entry nameiNAGK_ESCF3
    AccessioniPrimary (citable) accession number: B7LPQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3