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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:EFER_1175
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000745 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001361631 – 328D-cysteine desulfhydraseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB7LP46.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000022459.
KOiK05396.
OMAiTLWDDYF.
OrthoDBiPOG091H0B2C.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr. 1 hit.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LP46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQNLTRFP RLEFIGAPTP LEYLPRFSDY LGREIFIKRD DVTPLAMGGN
60 70 80 90 100
KVRKLEFLAA DALREGADTL VTAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTQAENY LSNGNRLLLD LFNVQVEMCA ALDDPDAQLQ ELATRIEAQG
160 170 180 190 200
FRPYVIPVGG SNALGALGYV ESALEIAQQC EGAVNLSSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLL PETELIGVTV SRSVADQKPK VVALQQAVAR ELELSAAAEI
260 270 280 290 300
TLWDEYFAPG YGTPNEEGME AVKLLARLEG ILLDPVYTGK AMAGLIDGIS
310 320
QKRFKDQGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):35,038
Last modified:February 10, 2009 - v1
Checksum:i4446BBB631D16EA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ88702.1.
RefSeqiWP_000058228.1. NC_011740.1.

Genome annotation databases

EnsemblBacteriaiCAQ88702; CAQ88702; EFER_1175.
KEGGiefe:EFER_1175.
PATRICi32126747. VBIEscFer122920_1133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ88702.1.
RefSeqiWP_000058228.1. NC_011740.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB7LP46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ88702; CAQ88702; EFER_1175.
KEGGiefe:EFER_1175.
PATRICi32126747. VBIEscFer122920_1133.

Phylogenomic databases

HOGENOMiHOG000022459.
KOiK05396.
OMAiTLWDDYF.
OrthoDBiPOG091H0B2C.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr. 1 hit.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCYD_ESCF3
AccessioniPrimary (citable) accession number: B7LP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.