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B7LNU8

- PNCB_ESCF3

UniProt

B7LNU8 - PNCB_ESCF3

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciEFER585054:GJJM-1067-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:EFER_1075
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000745: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Nicotinate phosphoribosyltransferasePRO_1000129474Add
BLAST

Proteomic databases

PRIDEiB7LNU8.

Interactioni

Protein-protein interaction databases

STRINGi585054.EFER_1075.

Structurei

3D structure databases

ProteinModelPortaliB7LNU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LNU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQFASPVLH SLLDTDAYKL HMQQAVFHHY HDVHVAAEFR CRGDDLLGIY
60 70 80 90 100
ADAIREQVHA MQHLRLQEEE FQWLTGLPFF KPDYLNWLRD FRYNPEQVSV
110 120 130 140 150
TNDNGKLNIR LTGPWLEVIM WEVPLLAVIS ELVHHYRSPE ASVQLAMNTL
160 170 180 190 200
EQKLADFTTL TAGLDMSRFH LMDFGTRRRF SRDVQEAIVK RLQQESWFVG
210 220 230 240 250
TSNYDLARRL SLTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLEEYPD
260 270 280 290 300
QLGIALTDCI TMDAFLRDFG VEFASRYQGL RHDSGDPVEW GEKAIAHYLK
310 320 330 340 350
LGIDPQSKVL VFSDNLDLTK AIELYRHFSS RIKLSFGIGT RLTCDIPQVK
360 370 380 390 400
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQIKKAS
Length:400
Mass (Da):45,849
Last modified:February 10, 2009 - v1
Checksum:iAD58DB45C9E652FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ88604.1.
RefSeqiYP_002382238.1. NC_011740.1.

Genome annotation databases

EnsemblBacteriaiCAQ88604; CAQ88604; EFER_1075.
GeneIDi7123182.
KEGGiefe:EFER_1075.
PATRICi32126549. VBIEscFer122920_1035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ88604.1 .
RefSeqi YP_002382238.1. NC_011740.1.

3D structure databases

ProteinModelPortali B7LNU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585054.EFER_1075.

Proteomic databases

PRIDEi B7LNU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ88604 ; CAQ88604 ; EFER_1075 .
GeneIDi 7123182.
KEGGi efe:EFER_1075.
PATRICi 32126549. VBIEscFer122920_1035.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci EFER585054:GJJM-1067-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35469 / DSM 13698 / CDC 0568-73.

Entry informationi

Entry nameiPNCB_ESCF3
AccessioniPrimary (citable) accession number: B7LNU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3