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B7LNU8

- PNCB_ESCF3

UniProt

B7LNU8 - PNCB_ESCF3

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciEFER585054:GJJM-1067-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:EFER_1075
    OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
    Taxonomic identifieri585054 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000745: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Nicotinate phosphoribosyltransferasePRO_1000129474Add
    BLAST

    Proteomic databases

    PRIDEiB7LNU8.

    Interactioni

    Protein-protein interaction databases

    STRINGi585054.EFER_1075.

    Structurei

    3D structure databases

    ProteinModelPortaliB7LNU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7LNU8-1 [UniParc]FASTAAdd to Basket

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    MTQFASPVLH SLLDTDAYKL HMQQAVFHHY HDVHVAAEFR CRGDDLLGIY    50
    ADAIREQVHA MQHLRLQEEE FQWLTGLPFF KPDYLNWLRD FRYNPEQVSV 100
    TNDNGKLNIR LTGPWLEVIM WEVPLLAVIS ELVHHYRSPE ASVQLAMNTL 150
    EQKLADFTTL TAGLDMSRFH LMDFGTRRRF SRDVQEAIVK RLQQESWFVG 200
    TSNYDLARRL SLTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLEEYPD 250
    QLGIALTDCI TMDAFLRDFG VEFASRYQGL RHDSGDPVEW GEKAIAHYLK 300
    LGIDPQSKVL VFSDNLDLTK AIELYRHFSS RIKLSFGIGT RLTCDIPQVK 350
    PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQIKKAS 400
    Length:400
    Mass (Da):45,849
    Last modified:February 10, 2009 - v1
    Checksum:iAD58DB45C9E652FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928158 Genomic DNA. Translation: CAQ88604.1.
    RefSeqiYP_002382238.1. NC_011740.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ88604; CAQ88604; EFER_1075.
    GeneIDi7123182.
    KEGGiefe:EFER_1075.
    PATRICi32126549. VBIEscFer122920_1035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928158 Genomic DNA. Translation: CAQ88604.1 .
    RefSeqi YP_002382238.1. NC_011740.1.

    3D structure databases

    ProteinModelPortali B7LNU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585054.EFER_1075.

    Proteomic databases

    PRIDEi B7LNU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ88604 ; CAQ88604 ; EFER_1075 .
    GeneIDi 7123182.
    KEGGi efe:EFER_1075.
    PATRICi 32126549. VBIEscFer122920_1035.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci EFER585054:GJJM-1067-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35469 / DSM 13698 / CDC 0568-73.

    Entry informationi

    Entry nameiPNCB_ESCF3
    AccessioniPrimary (citable) accession number: B7LNU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3