ID   B7LNI6_ESCF3            Unreviewed;       234 AA.
AC   B7LNI6;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759,
GN   ECO:0000313|EMBL:CAQ90259.1};
GN   OrderedLocusNames=EFER_2764 {ECO:0000313|EMBL:CAQ90259.1};
OS   Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS   14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585054 {ECO:0000313|EMBL:CAQ90259.1, ECO:0000313|Proteomes:UP000000745};
RN   [1] {ECO:0000313|Proteomes:UP000000745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 /
RC   JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73
RC   {ECO:0000313|Proteomes:UP000000745};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
CC       GATC sequences. It is involved in DNA mismatch repair.
CC       {ECO:0000256|HAMAP-Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; CU928158; CAQ90259.1; -; Genomic_DNA.
DR   AlphaFoldDB; B7LNI6; -.
DR   KEGG; efe:EFER_2764; -.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   Proteomes; UP000000745; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH-like; 1.
DR   Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00759};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00759};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW   Rule:MF_00759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759}.
FT   DOMAIN          62..160
FT                   /note="DNA mismatch repair MutH/Type II restriction enzyme
FT                   Sau3AI"
FT                   /evidence="ECO:0000259|SMART:SM00927"
SQ   SEQUENCE   234 AA;  25824 MW;  1413265855FF5933 CRC64;
     MNSMPDIRPL LTSPASEAEL LAQAQQLSGY TLGELAALAG MVTPKDLKRD KGWIGVLLEI
     WLGASAGSKP EQDFAALGVE LKTIPVDSLG RPLETTFVCV APLTGNTGVT WETSHVRHKL
     KRVLWIPVEG ERSIPLAQRR VGSPLLWSPN EEEDRQLRLD WEELMDMIVL GRVERITARH
     GEVLQLRPKA ANAKALTEAI GANGEPILTL PRGFYLKKNF TSALLARHFL IQQP
//