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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA modification Source: InterPro
  2. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciEFER585054:GJJM-2768-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotationSAAS annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotationImported
Ordered Locus Names:EFER_2764Imported
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)Imported
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000745 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi585054.EFER_2764.

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LNI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSMPDIRPL LTSPASEAEL LAQAQQLSGY TLGELAALAG MVTPKDLKRD
60 70 80 90 100
KGWIGVLLEI WLGASAGSKP EQDFAALGVE LKTIPVDSLG RPLETTFVCV
110 120 130 140 150
APLTGNTGVT WETSHVRHKL KRVLWIPVEG ERSIPLAQRR VGSPLLWSPN
160 170 180 190 200
EEEDRQLRLD WEELMDMIVL GRVERITARH GEVLQLRPKA ANAKALTEAI
210 220 230
GANGEPILTL PRGFYLKKNF TSALLARHFL IQQP
Length:234
Mass (Da):25,824
Last modified:February 10, 2009 - v1
Checksum:i1413265855FF5933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ90259.1.
RefSeqiYP_002383870.1. NC_011740.1.

Genome annotation databases

EnsemblBacteriaiCAQ90259; CAQ90259; EFER_2764.
GeneIDi7119673.
KEGGiefe:EFER_2764.
PATRICi32129901. VBIEscFer122920_2678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA. Translation: CAQ90259.1.
RefSeqiYP_002383870.1. NC_011740.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi585054.EFER_2764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ90259; CAQ90259; EFER_2764.
GeneIDi7119673.
KEGGiefe:EFER_2764.
PATRICi32129901. VBIEscFer122920_2678.

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Enzyme and pathway databases

BioCyciEFER585054:GJJM-2768-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35469 / DSM 13698 / CDC 0568-73Imported.

Entry informationi

Entry nameiB7LNI6_ESCF3
AccessioniPrimary (citable) accession number: B7LNI6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: March 4, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.