Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80UniRule annotation1
Active sitei143UniRule annotation1
Active sitei166UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:EFER_2401
OrganismiEscherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Taxonomic identifieri585054 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000745 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001239961 – 214Pyrrolidone-carboxylate peptidaseAdd BLAST214

Proteomic databases

PRIDEiB7LKQ5

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7LKQ5
SMRiB7LKQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242641
KOiK01304
OMAiVCNHVFY
OrthoDBiPOG091H07B8

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

B7LKQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVLITGFE PFGGEQINPS WEVVSQLDNA ILGGCRVVAR QLPCVFGESL
60 70 80 90 100
AVLNSAIDAL SPSVVLAVGQ AGGRTDITVE RVAINVDDAR IPDNRGNQPV
110 120 130 140 150
DVPVIPNGPA AWFSTLPIKA MVSAIREAGI PASVSQTAGT FVCNHVMYGL
160 170 180 190 200
LHKLSSMADV KGGFIHIPYL PQQAAAHPGA PSMAADTVRR ALETAIITAL
210
YVDADIIVAG GATH
Length:214
Mass (Da):22,287
Last modified:February 10, 2009 - v1
Checksum:i6E07918D3C32F5A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928158 Genomic DNA Translation: CAQ89900.1
RefSeqiWP_000859694.1, NC_011740.1

Genome annotation databases

EnsemblBacteriaiCAQ89900; CAQ89900; EFER_2401
KEGGiefe:EFER_2401

Similar proteinsi

Entry informationi

Entry nameiPCP_ESCF3
AccessioniPrimary (citable) accession number: B7LKQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health