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Protein

Ribonuclease HII

Gene

rnhB

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Divalent metal cationUniRule annotation1
Metal bindingi17Divalent metal cationUniRule annotation1
Metal bindingi108Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:EC55989_0177
OrganismiEscherichia coli (strain 55989 / EAEC)
Taxonomic identifieri585055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000746 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001944501 – 198Ribonuclease HIIAdd BLAST198

Structurei

3D structure databases

ProteinModelPortaliB7LGP5
SMRiB7LGP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000100288
KOiK03470
OMAiNILHASM

Family and domain databases

CDDicd07182 RNase_HII_bacteria_HII_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00052_B RNase_HII_B, 1 hit
InterProiView protein in InterPro
IPR022898 RNase_HII
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PTHR10954:SF18 PTHR10954:SF18, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

B7LGP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEFVYPHTQ LVAGVDEVGR GPLVGAVVTA AVILDPARPI AGLNDSKKLS
60 70 80 90 100
EKRRLALYEE IKEKALSWSL GRAEPHEIDE LNILHATMLA MQRAVAGLHI
110 120 130 140 150
APEYVLIDGN RCPKLPMPAM AVVKGDSRVP EISAASILAK VTRDAEMAAL
160 170 180 190
DIVFPQYGFA QHKGYPTAFH LEKLAEHGAT EHHRRSFGPV KRALGLAS
Length:198
Mass (Da):21,526
Last modified:February 10, 2009 - v1
Checksum:i25350722EB5D7864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928145 Genomic DNA Translation: CAU96063.1
RefSeqiWP_000569430.1, NC_011748.1

Genome annotation databases

EnsemblBacteriaiCAU96063; CAU96063; EC55989_0177
KEGGieck:EC55989_0177

Similar proteinsi

Entry informationi

Entry nameiRNH2_ECO55
AccessioniPrimary (citable) accession number: B7LGP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: November 22, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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