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B7LCQ5

- ULAD_ECO55

UniProt

B7LCQ5 - ULAD_ECO55

Protein

3-keto-L-gulonate-6-phosphate decarboxylase UlaD

Gene

ulaD

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.UniRule annotation

    Catalytic activityi

    3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Metal bindingi33 – 331MagnesiumUniRule annotation
    Metal bindingi62 – 621MagnesiumUniRule annotation
    Sitei64 – 641Transition state stabilizerUniRule annotation
    Sitei67 – 671Transition state stabilizerUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-dehydro-L-gulonate-6-phosphate decarboxylase activity Source: UniProtKB-EC
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. orotidine-5'-phosphate decarboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. L-ascorbic acid catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciECOL585055:GJOM-4826-MONOMER.
    UniPathwayiUPA00263; UER00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-keto-L-gulonate-6-phosphate decarboxylase UlaDUniRule annotation (EC:4.1.1.85UniRule annotation)
    Alternative name(s):
    3-dehydro-L-gulonate-6-phosphate decarboxylaseUniRule annotation
    KGPDCUniRule annotation
    L-ascorbate utilization protein DUniRule annotation
    Gene namesi
    Name:ulaDUniRule annotation
    Ordered Locus Names:EC55989_4753
    OrganismiEscherichia coli (strain 55989 / EAEC)
    Taxonomic identifieri585055 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000746: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2162163-keto-L-gulonate-6-phosphate decarboxylase UlaDPRO_1000165141Add
    BLAST

    Expressioni

    Inductioni

    Induced by L-ascorbate. Repressed by UlaR.UniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi585055.EC55989_4753.

    Structurei

    3D structure databases

    ProteinModelPortaliB7LCQ5.
    SMRiB7LCQ5. Positions 2-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HPS/KGPDC family. KGPDC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0269.
    HOGENOMiHOG000226068.
    KOiK03078.
    OMAiSHAYETT.
    OrthoDBiEOG66B435.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01267. UlaD.
    InterProiIPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
    IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7LCQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPMLQVAL DNQTMDSAYE TTRLIAEEVD IIEVGTILCV GEGVRAVRDL    50
    KALYPHKIVL ADAKIADAGK ILSRMCFEAN ADWVTVICCA DINTAKGALD 100
    VAKEFNGDVQ IELTGYWTWE QAQQWRDAGI QQVVYHRSRD AQAAGVAWGE 150
    ADITAIKRLS DMGFKVTVTG GLALEDLPLF KGIPIHVFIA GRSIRDAASP 200
    VEAARQFKRS IAELWG 216
    Length:216
    Mass (Da):23,649
    Last modified:February 10, 2009 - v1
    Checksum:iCDF287AC1D1BAD68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAV01690.1.
    RefSeqiYP_002405613.1. NC_011748.1.

    Genome annotation databases

    EnsemblBacteriaiCAV01690; CAV01690; EC55989_4753.
    GeneIDi7147915.
    KEGGieck:EC55989_4753.
    PATRICi38483098. VBIEscCol113220_4776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAV01690.1 .
    RefSeqi YP_002405613.1. NC_011748.1.

    3D structure databases

    ProteinModelPortali B7LCQ5.
    SMRi B7LCQ5. Positions 2-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585055.EC55989_4753.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAV01690 ; CAV01690 ; EC55989_4753 .
    GeneIDi 7147915.
    KEGGi eck:EC55989_4753.
    PATRICi 38483098. VBIEscCol113220_4776.

    Phylogenomic databases

    eggNOGi COG0269.
    HOGENOMi HOG000226068.
    KOi K03078.
    OMAi SHAYETT.
    OrthoDBi EOG66B435.

    Enzyme and pathway databases

    UniPathwayi UPA00263 ; UER00378 .
    BioCyci ECOL585055:GJOM-4826-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01267. UlaD.
    InterProi IPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
    IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 55989 / EAEC.

    Entry informationi

    Entry nameiULAD_ECO55
    AccessioniPrimary (citable) accession number: B7LCQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3