SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7LCQ5

- ULAD_ECO55

UniProt

B7LCQ5 - ULAD_ECO55

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
3-keto-L-gulonate-6-phosphate decarboxylase UlaD
Gene
ulaD, EC55989_4753
Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization By similarity.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Metal bindingi33 – 331Magnesium By similarity
Metal bindingi62 – 621Magnesium By similarity
Sitei64 – 641Transition state stabilizer By similarity
Sitei67 – 671Transition state stabilizer By similarity
Binding sitei192 – 1921Substrate By similarity

GO - Molecular functioni

  1. 3-dehydro-L-gulonate-6-phosphate decarboxylase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. orotidine-5'-phosphate decarboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. L-ascorbic acid catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciECOL585055:GJOM-4826-MONOMER.
UniPathwayiUPA00263; UER00378.

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-L-gulonate-6-phosphate decarboxylase UlaD (EC:4.1.1.85)
Alternative name(s):
3-dehydro-L-gulonate-6-phosphate decarboxylase
KGPDC
L-ascorbate utilization protein D
Gene namesi
Name:ulaD
Ordered Locus Names:EC55989_4753
OrganismiEscherichia coli (strain 55989 / EAEC)
Taxonomic identifieri585055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000746: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2162163-keto-L-gulonate-6-phosphate decarboxylase UlaDUniRule annotation
PRO_1000165141Add
BLAST

Expressioni

Inductioni

Induced by L-ascorbate. Repressed by UlaR By similarity.UniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi585055.EC55989_4753.

Structurei

3D structure databases

ProteinModelPortaliB7LCQ5.
SMRiB7LCQ5. Positions 2-216.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0269.
HOGENOMiHOG000226068.
KOiK03078.
OMAiSHAYETT.
OrthoDBiEOG66B435.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01267. UlaD.
InterProiIPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LCQ5-1 [UniParc]FASTAAdd to Basket

« Hide

MSLPMLQVAL DNQTMDSAYE TTRLIAEEVD IIEVGTILCV GEGVRAVRDL    50
KALYPHKIVL ADAKIADAGK ILSRMCFEAN ADWVTVICCA DINTAKGALD 100
VAKEFNGDVQ IELTGYWTWE QAQQWRDAGI QQVVYHRSRD AQAAGVAWGE 150
ADITAIKRLS DMGFKVTVTG GLALEDLPLF KGIPIHVFIA GRSIRDAASP 200
VEAARQFKRS IAELWG 216
Length:216
Mass (Da):23,649
Last modified:February 10, 2009 - v1
Checksum:iCDF287AC1D1BAD68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAV01690.1.
RefSeqiYP_002405613.1. NC_011748.1.

Genome annotation databases

EnsemblBacteriaiCAV01690; CAV01690; EC55989_4753.
GeneIDi7147915.
KEGGieck:EC55989_4753.
PATRICi38483098. VBIEscCol113220_4776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAV01690.1 .
RefSeqi YP_002405613.1. NC_011748.1.

3D structure databases

ProteinModelPortali B7LCQ5.
SMRi B7LCQ5. Positions 2-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585055.EC55989_4753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV01690 ; CAV01690 ; EC55989_4753 .
GeneIDi 7147915.
KEGGi eck:EC55989_4753.
PATRICi 38483098. VBIEscCol113220_4776.

Phylogenomic databases

eggNOGi COG0269.
HOGENOMi HOG000226068.
KOi K03078.
OMAi SHAYETT.
OrthoDBi EOG66B435.

Enzyme and pathway databases

UniPathwayi UPA00263 ; UER00378 .
BioCyci ECOL585055:GJOM-4826-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01267. UlaD.
InterProi IPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 55989 / EAEC.

Entry informationi

Entry nameiULAD_ECO55
AccessioniPrimary (citable) accession number: B7LCQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi