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B7LCQ5

- ULAD_ECO55

UniProt

B7LCQ5 - ULAD_ECO55

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Protein

3-keto-L-gulonate-6-phosphate decarboxylase UlaD

Gene

ulaD

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Metal bindingi33 – 331MagnesiumUniRule annotation
Metal bindingi62 – 621MagnesiumUniRule annotation
Sitei64 – 641Transition state stabilizerUniRule annotation
Sitei67 – 671Transition state stabilizerUniRule annotation
Binding sitei192 – 1921SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-dehydro-L-gulonate-6-phosphate decarboxylase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. orotidine-5'-phosphate decarboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. L-ascorbic acid catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciECOL585055:GJOM-4826-MONOMER.
UniPathwayiUPA00263; UER00378.

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-L-gulonate-6-phosphate decarboxylase UlaDUniRule annotation (EC:4.1.1.85UniRule annotation)
Alternative name(s):
3-dehydro-L-gulonate-6-phosphate decarboxylaseUniRule annotation
KGPDCUniRule annotation
L-ascorbate utilization protein DUniRule annotation
Gene namesi
Name:ulaDUniRule annotation
Ordered Locus Names:EC55989_4753
OrganismiEscherichia coli (strain 55989 / EAEC)
Taxonomic identifieri585055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000746: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2162163-keto-L-gulonate-6-phosphate decarboxylase UlaDPRO_1000165141Add
BLAST

Expressioni

Inductioni

Induced by L-ascorbate. Repressed by UlaR.UniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi585055.EC55989_4753.

Structurei

3D structure databases

ProteinModelPortaliB7LCQ5.
SMRiB7LCQ5. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPS/KGPDC family. KGPDC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0269.
HOGENOMiHOG000226068.
KOiK03078.
OMAiSHAYETT.
OrthoDBiEOG66B435.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01267. UlaD.
InterProiIPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LCQ5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPMLQVAL DNQTMDSAYE TTRLIAEEVD IIEVGTILCV GEGVRAVRDL
60 70 80 90 100
KALYPHKIVL ADAKIADAGK ILSRMCFEAN ADWVTVICCA DINTAKGALD
110 120 130 140 150
VAKEFNGDVQ IELTGYWTWE QAQQWRDAGI QQVVYHRSRD AQAAGVAWGE
160 170 180 190 200
ADITAIKRLS DMGFKVTVTG GLALEDLPLF KGIPIHVFIA GRSIRDAASP
210
VEAARQFKRS IAELWG
Length:216
Mass (Da):23,649
Last modified:February 10, 2009 - v1
Checksum:iCDF287AC1D1BAD68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAV01690.1.
RefSeqiYP_002405613.1. NC_011748.1.

Genome annotation databases

EnsemblBacteriaiCAV01690; CAV01690; EC55989_4753.
GeneIDi7147915.
KEGGieck:EC55989_4753.
PATRICi38483098. VBIEscCol113220_4776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAV01690.1 .
RefSeqi YP_002405613.1. NC_011748.1.

3D structure databases

ProteinModelPortali B7LCQ5.
SMRi B7LCQ5. Positions 2-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585055.EC55989_4753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV01690 ; CAV01690 ; EC55989_4753 .
GeneIDi 7147915.
KEGGi eck:EC55989_4753.
PATRICi 38483098. VBIEscCol113220_4776.

Phylogenomic databases

eggNOGi COG0269.
HOGENOMi HOG000226068.
KOi K03078.
OMAi SHAYETT.
OrthoDBi EOG66B435.

Enzyme and pathway databases

UniPathwayi UPA00263 ; UER00378 .
BioCyci ECOL585055:GJOM-4826-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01267. UlaD.
InterProi IPR023942. 3-keto-L-gulonate6Pdecase_UlaD.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 55989 / EAEC.

Entry informationi

Entry nameiULAD_ECO55
AccessioniPrimary (citable) accession number: B7LCQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3