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B7LAS9

- MENH_ECO55

UniProt

B7LAS9 - MENH_ECO55

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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciECOL585055:GJOM-2562-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:EC55989_2511
OrganismiEscherichia coli (strain 55989 / EAEC)
Taxonomic identifieri585055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000746: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_1000187105Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi585055.EC55989_2511.

Structurei

3D structure databases

ProteinModelPortaliB7LAS9.
SMRiB7LAS9. Positions 3-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiLGGRIAM.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B7LAS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILHAQAKHG KPGLPWLVFL HGFSGDCHEW QEVGEAFADY SRLYVDLPGH
60 70 80 90 100
GGSAAISVDG FDDVTDLLRK TLVSYNILDF WLVGYSLGGR VAMMAACQGL
110 120 130 140 150
AGLCGVIVEG GHPGLQNAEQ RAERQRSDRQ WAQRFRTEPL TAVFADWYQQ
160 170 180 190 200
PVFASLNDDQ RRELVALRSN NNGATLAAML EATSLAVQPD LRANLSARTF
210 220 230 240 250
AFYYLCGERD SKFRALAAEL AADCHVIPRA GHNAHRENPA GVIASLAQIL

RF
Length:252
Mass (Da):27,697
Last modified:February 10, 2009 - v1
Checksum:i066D7E861099DAE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAU98379.1.
RefSeqiYP_002403533.1. NC_011748.1.

Genome annotation databases

EnsemblBacteriaiCAU98379; CAU98379; EC55989_2511.
GeneIDi7146818.
KEGGieck:EC55989_2511.
PATRICi38478517. VBIEscCol113220_2551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAU98379.1 .
RefSeqi YP_002403533.1. NC_011748.1.

3D structure databases

ProteinModelPortali B7LAS9.
SMRi B7LAS9. Positions 3-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585055.EC55989_2511.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAU98379 ; CAU98379 ; EC55989_2511 .
GeneIDi 7146818.
KEGGi eck:EC55989_2511.
PATRICi 38478517. VBIEscCol113220_2551.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028072.
KOi K08680.
OMAi LGGRIAM.
OrthoDBi EOG689HPM.

Enzyme and pathway databases

UniPathwayi UPA00079 .
UPA01057 ; UER00900 .
BioCyci ECOL585055:GJOM-2562-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01660. MenH.
InterProi IPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 55989 / EAEC.

Entry informationi

Entry nameiMENH_ECO55
AccessioniPrimary (citable) accession number: B7LAS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3