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B7LAS9

- MENH_ECO55

UniProt

B7LAS9 - MENH_ECO55

Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.UniRule annotation

    Catalytic activityi

    5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Enzyme and pathway databases

    BioCyciECOL585055:GJOM-2562-MONOMER.
    UniPathwayiUPA00079; UER00900.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
    Short name:
    SHCHC synthaseUniRule annotation
    Gene namesi
    Name:menHUniRule annotation
    Ordered Locus Names:EC55989_2511
    OrganismiEscherichia coli (strain 55989 / EAEC)
    Taxonomic identifieri585055 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000746: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_1000187105Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi585055.EC55989_2511.

    Structurei

    3D structure databases

    ProteinModelPortaliB7LAS9.
    SMRiB7LAS9. Positions 3-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028072.
    KOiK08680.
    OMAiLGGRIAM.
    OrthoDBiEOG689HPM.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    HAMAPiMF_01660. MenH.
    InterProiIPR029058. AB_hydrolase.
    IPR022485. SHCHC_synthase_MenH.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7LAS9-1 [UniParc]FASTAAdd to Basket

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    MILHAQAKHG KPGLPWLVFL HGFSGDCHEW QEVGEAFADY SRLYVDLPGH    50
    GGSAAISVDG FDDVTDLLRK TLVSYNILDF WLVGYSLGGR VAMMAACQGL 100
    AGLCGVIVEG GHPGLQNAEQ RAERQRSDRQ WAQRFRTEPL TAVFADWYQQ 150
    PVFASLNDDQ RRELVALRSN NNGATLAAML EATSLAVQPD LRANLSARTF 200
    AFYYLCGERD SKFRALAAEL AADCHVIPRA GHNAHRENPA GVIASLAQIL 250
    RF 252
    Length:252
    Mass (Da):27,697
    Last modified:February 10, 2009 - v1
    Checksum:i066D7E861099DAE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAU98379.1.
    RefSeqiYP_002403533.1. NC_011748.1.

    Genome annotation databases

    EnsemblBacteriaiCAU98379; CAU98379; EC55989_2511.
    GeneIDi7146818.
    KEGGieck:EC55989_2511.
    PATRICi38478517. VBIEscCol113220_2551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAU98379.1 .
    RefSeqi YP_002403533.1. NC_011748.1.

    3D structure databases

    ProteinModelPortali B7LAS9.
    SMRi B7LAS9. Positions 3-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585055.EC55989_2511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAU98379 ; CAU98379 ; EC55989_2511 .
    GeneIDi 7146818.
    KEGGi eck:EC55989_2511.
    PATRICi 38478517. VBIEscCol113220_2551.

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028072.
    KOi K08680.
    OMAi LGGRIAM.
    OrthoDBi EOG689HPM.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00900 .
    BioCyci ECOL585055:GJOM-2562-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    HAMAPi MF_01660. MenH.
    InterProi IPR029058. AB_hydrolase.
    IPR022485. SHCHC_synthase_MenH.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 55989 / EAEC.

    Entry informationi

    Entry nameiMENH_ECO55
    AccessioniPrimary (citable) accession number: B7LAS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3