ID   B7L8G0_ECO55            Unreviewed;       217 AA.
AC   B7L8G0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=NfnB protein {ECO:0000313|EMBL:CAU96442.1};
DE            EC=1.5.1.34 {ECO:0000313|EMBL:CAU96442.1};
GN   Name=nfnB {ECO:0000313|EMBL:CAU96442.1};
GN   OrderedLocusNames=EC55989_0569 {ECO:0000313|EMBL:CAU96442.1};
OS   Escherichia coli (strain 55989 / EAEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585055 {ECO:0000313|EMBL:CAU96442.1, ECO:0000313|Proteomes:UP000000746};
RN   [1] {ECO:0000313|Proteomes:UP000000746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=55989 / EAEC {ECO:0000313|Proteomes:UP000000746};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
CC   -!- SIMILARITY: Belongs to the nitroreductase family.
CC       {ECO:0000256|ARBA:ARBA00007118}.
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DR   EMBL; CU928145; CAU96442.1; -; Genomic_DNA.
DR   RefSeq; WP_000351464.1; NC_011748.1.
DR   AlphaFoldDB; B7L8G0; -.
DR   GeneID; 75170580; -.
DR   KEGG; eck:EC55989_0569; -.
DR   HOGENOM; CLU_070764_4_1_6; -.
DR   Proteomes; UP000000746; Chromosome.
DR   GO; GO:0004155; F:6,7-dihydropteridine reductase activity; IEA:UniProtKB-EC.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR23026; NADPH NITROREDUCTASE; 1.
DR   PANTHER; PTHR23026:SF125; OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000313|EMBL:CAU96442.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000746}.
FT   DOMAIN          8..193
FT                   /note="Nitroreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00881"
SQ   SEQUENCE   217 AA;  23859 MW;  167B11EC323B7BD5 CRC64;
     MDIISVALKR HSTKAFDASK KLTPEQAEQI KTLLQYSPSS TNSQPWHFIV ASTEEGKARV
     AKSAAGNYVF NERKILDASH VVVFCAKTAM DDAWLKLVVD QEDADGRFAT PEAKAANDKG
     RKFFADMHRK DLHDDAEWMA KQVYLNVGNF LLGVAALGLD AVPIEGFDAA ILDAEFGLKE
     KGYTSLVVVP VGHHSVEDFN ATLPKSRLPQ NITLTEV
//