Skip Header

Contribute Send feedback
Read comments (?) or add your own

B7L603 (TREF_ECO55) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytoplasmic trehalase
EC=3.2.1.28
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene names
Name:treF
Ordered Locus Names:EC55989_3964
OrganismEscherichia coli (strain 55989 / EAEC) [Complete proteome] [HAMAP]
Taxonomic identifier585055 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity By similarity. HAMAP MF_01059

Catalytic activity

Alpha,alpha-trehalose + H2O = 2 D-glucose. HAMAP MF_01059

Pathway

Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1. HAMAP MF_01059

Subunit structure

Monomer By similarity. HAMAP MF_01059

Subcellular location

Cytoplasm By similarity HAMAP MF_01059.

Sequence similarities

Belongs to the glycosyl hydrolase 37 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcellular hyperosmotic response

Inferred from electronic annotation. Source: InterPro

trehalose catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalpha,alpha-trehalase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Cytoplasmic trehalase HAMAP MF_01059
PRO_1000149680

Sequences

Sequence LengthMass (Da)Tools
B7L603 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 2BD4992BCE5655C3

FASTA54963,784
        10         20         30         40         50         60 
MLNQKIQNPN PDELMIEVDL CYELDPYELK LDEMIEAEPE PEMIEGLPAS DALTPADRYL 

        70         80         90        100        110        120 
ELFEHVQSAK IFPDSKTFPD CAPKMDPLDI LIRYRKVRRH RDFDLRKFVE NHFWLPEVYS 

       130        140        150        160        170        180 
REYVSDPQNS LKEHIDQLWP VLTREPQDHI PWSSLLALPQ SYIVPGGRFS ETYYWDSYFT 

       190        200        210        220        230        240 
MLGLAESGRE DLLKCMADNF AWMIENYGHI PNGNRTYYLS RSQPPVFALM VELFEEDGVR 

       250        260        270        280        290        300 
GARRYLDHLK MEYAFWMDGA ESLIPNQAYR HVVRMPDGSL LNRYWDDRDT PRDESWLEDV 

       310        320        330        340        350        360 
ETAKHSGRPP NEVYRDLRAG AASGWDYSSR WLRDTGRLAS IRTTQFIPID LNAFLFKLES 

       370        380        390        400        410        420 
AIANISALKG EKETEALFRQ KASARRDAVN RYLWDDENGI YRDYDWRREQ LALFSAAAIV 

       430        440        450        460        470        480 
PLYVGMANHE QADRLANAVR SRLLTPGGIL ASEYETGEQW DKPNGWAPLQ WMAIQGFKMY 

       490        500        510        520        530        540 
GDDLLGDEIA RSWLKTVNQF YLEQHKMIEK YHIADGVPRE GGGGEYPLQD GFGWTNGVVR 


RLIGLYGEP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU928145 Genomic DNA. Translation: CAV00416.1.
RefSeqYP_002404895.1. NC_011748.1.

3D structure databases

ProteinModelPortalB7L603.
SMRB7L603. Positions 53-548.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7L603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000131216; EBESCP00000121256; EBESCG00000125875.
GeneID7149006.
GenomeReviewsGene locus EC55989_3964 in contig CU928145_GR.
KEGGeck:EC55989_3964.
PATRIC38481472. VBIEscCol113220_3996.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000010574.
HOGENOMHBG485982.
OMAFWMDGAD.
ProtClustDBPRK13270.

Enzyme and pathway databases

BioCycECOL585055:EC55989_3964-MONOMER.

Family and domain databases

HAMAPMF_01059. Cyt_trehalase.
[Tree]
InterProIPR008928. 6-hairpin_glycosidase-like.
IPR023715. Cyt_trehalase.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
KOK01194.
PANTHERPTHR23403. Glyco_hydro_37. 1 hit.
PfamPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSPR00744. GLHYDRLASE37.
SUPFAMSSF48208. Glyco_trans_6hp. 1 hit.
PROSITEPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTREF_ECO55
AccessionPrimary (citable) accession number: B7L603
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents