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B7L503

- MHPA_ECO55

UniProt

B7L503 - MHPA_ECO55

Protein

3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase

Gene

mhpA

Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).UniRule annotation

    Catalytic activityi

    3-(3-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+.UniRule annotation
    (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 4630FADUniRule annotationAdd
    BLAST
    Nucleotide bindingi285 – 29511FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 3-(3-hydroxyphenyl)propionate hydroxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 3-(3-hydroxy)phenylpropionate catabolic process Source: UniProtKB-HAMAP
    2. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciECOL585055:GJOM-361-MONOMER.
    UniPathwayiUPA00714.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylaseUniRule annotation (EC:1.14.13.127UniRule annotation)
    Short name:
    3-HCI hydroxylaseUniRule annotation
    Short name:
    3-HPP hydroxylaseUniRule annotation
    Gene namesi
    Name:mhpAUniRule annotation
    Ordered Locus Names:EC55989_0354
    OrganismiEscherichia coli (strain 55989 / EAEC)
    Taxonomic identifieri585055 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000746: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5545543-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylasePRO_1000186989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi585055.EC55989_0354.

    Structurei

    3D structure databases

    ProteinModelPortaliB7L503.
    SMRiB7L503. Positions 15-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PheA/TfdB FAD monooxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0654.
    HOGENOMiHOG000221401.
    KOiK05712.
    OMAiRNRISAW.
    OrthoDBiEOG63RGN4.

    Family and domain databases

    HAMAPiMF_01652. MhpA.
    InterProiIPR023786. 3-HPP/3HCI_hydroxylase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequencei

    Sequence statusi: Complete.

    B7L503-1 [UniParc]FASTAAdd to Basket

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    MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL    50
    IDYPRAIGID DEALRTMQSV GLVDDVLPHT TPWHAMRFLT PKGRCFADIQ 100
    PMTDEFGWPR RNAFIQPQVD AVMLEGVSRF PNVRCLFSRE LEAFSQQDDE 150
    VTLHLKTAEG QREIVKAQWL VACDGGASFV RRTLNVPFEG KTAPNQWIVV 200
    DIANDPLSTP HIYLCCDPVR PYVSAALPHA VRRFEFMVMP GETEEQLREP 250
    QNMRKLLSKV LPNPDNVELI RQRVYTHNAR LAQRFRIDRV LLAGDAAHIM 300
    PVWQGQGYNS GMRDAFNLAW KLALVIQGKA RDALLDTYQQ ERRDHAKAMI 350
    DLSVTAGNVL APPKRWQGTL RDGVSWLLNY LPPVKRYFLE MRFKPMPQYY 400
    GGALVREGEA KHSPVGKMFI QPKVTLENGD VTLLDNAIGA NFAVIGWGCN 450
    PLWGMSDEQI QQWRALGTRF IQVVPEVQIH TAQDNHDGVL RVGDTQGRLR 500
    SWFAQHNASL VVMRPDRFVA ATAIPQTLGK TLNKLASVMT LTRPDADVSV 550
    EKVA 554
    Length:554
    Mass (Da):62,154
    Last modified:February 10, 2009 - v1
    Checksum:i1CFDCB632F3F3A24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAU96231.1.
    RefSeqiYP_002401478.1. NC_011748.1.

    Genome annotation databases

    EnsemblBacteriaiCAU96231; CAU96231; EC55989_0354.
    GeneIDi7146850.
    KEGGieck:EC55989_0354.
    PATRICi38474058. VBIEscCol113220_0362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928145 Genomic DNA. Translation: CAU96231.1 .
    RefSeqi YP_002401478.1. NC_011748.1.

    3D structure databases

    ProteinModelPortali B7L503.
    SMRi B7L503. Positions 15-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585055.EC55989_0354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAU96231 ; CAU96231 ; EC55989_0354 .
    GeneIDi 7146850.
    KEGGi eck:EC55989_0354.
    PATRICi 38474058. VBIEscCol113220_0362.

    Phylogenomic databases

    eggNOGi COG0654.
    HOGENOMi HOG000221401.
    KOi K05712.
    OMAi RNRISAW.
    OrthoDBi EOG63RGN4.

    Enzyme and pathway databases

    UniPathwayi UPA00714 .
    BioCyci ECOL585055:GJOM-361-MONOMER.

    Family and domain databases

    HAMAPi MF_01652. MhpA.
    InterProi IPR023786. 3-HPP/3HCI_hydroxylase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 55989 / EAEC.

    Entry informationi

    Entry nameiMHPA_ECO55
    AccessioniPrimary (citable) accession number: B7L503
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3