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B7L503

- MHPA_ECO55

UniProt

B7L503 - MHPA_ECO55

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Protein

3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase

Gene
mhpA, EC55989_0354
Organism
Escherichia coli (strain 55989 / EAEC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI) By similarity.UniRule annotation

Catalytic activityi

3-(3-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+.UniRule annotation
(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 4630FAD Reviewed predictionAdd
BLAST
Nucleotide bindingi285 – 29511FAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. 3-(3-hydroxyphenyl)propionate hydroxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 3-(3-hydroxy)phenylpropionate catabolic process Source: UniProtKB-HAMAP
  2. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciECOL585055:GJOM-361-MONOMER.
UniPathwayiUPA00714.

Names & Taxonomyi

Protein namesi
Recommended name:
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase (EC:1.14.13.127)
Short name:
3-HCI hydroxylase
Short name:
3-HPP hydroxylase
Gene namesi
Name:mhpA
Ordered Locus Names:EC55989_0354
OrganismiEscherichia coli (strain 55989 / EAEC)
Taxonomic identifieri585055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000746: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5545543-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylaseUniRule annotationPRO_1000186989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi585055.EC55989_0354.

Structurei

3D structure databases

ProteinModelPortaliB7L503.
SMRiB7L503. Positions 15-543.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0654.
HOGENOMiHOG000221401.
KOiK05712.
OMAiRNRISAW.
OrthoDBiEOG63RGN4.

Family and domain databases

HAMAPiMF_01652. MhpA.
InterProiIPR023786. 3-HPP/3HCI_hydroxylase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

B7L503-1 [UniParc]FASTAAdd to Basket

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MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL    50
IDYPRAIGID DEALRTMQSV GLVDDVLPHT TPWHAMRFLT PKGRCFADIQ 100
PMTDEFGWPR RNAFIQPQVD AVMLEGVSRF PNVRCLFSRE LEAFSQQDDE 150
VTLHLKTAEG QREIVKAQWL VACDGGASFV RRTLNVPFEG KTAPNQWIVV 200
DIANDPLSTP HIYLCCDPVR PYVSAALPHA VRRFEFMVMP GETEEQLREP 250
QNMRKLLSKV LPNPDNVELI RQRVYTHNAR LAQRFRIDRV LLAGDAAHIM 300
PVWQGQGYNS GMRDAFNLAW KLALVIQGKA RDALLDTYQQ ERRDHAKAMI 350
DLSVTAGNVL APPKRWQGTL RDGVSWLLNY LPPVKRYFLE MRFKPMPQYY 400
GGALVREGEA KHSPVGKMFI QPKVTLENGD VTLLDNAIGA NFAVIGWGCN 450
PLWGMSDEQI QQWRALGTRF IQVVPEVQIH TAQDNHDGVL RVGDTQGRLR 500
SWFAQHNASL VVMRPDRFVA ATAIPQTLGK TLNKLASVMT LTRPDADVSV 550
EKVA 554
Length:554
Mass (Da):62,154
Last modified:February 10, 2009 - v1
Checksum:i1CFDCB632F3F3A24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAU96231.1.
RefSeqiYP_002401478.1. NC_011748.1.

Genome annotation databases

EnsemblBacteriaiCAU96231; CAU96231; EC55989_0354.
GeneIDi7146850.
KEGGieck:EC55989_0354.
PATRICi38474058. VBIEscCol113220_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928145 Genomic DNA. Translation: CAU96231.1 .
RefSeqi YP_002401478.1. NC_011748.1.

3D structure databases

ProteinModelPortali B7L503.
SMRi B7L503. Positions 15-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585055.EC55989_0354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAU96231 ; CAU96231 ; EC55989_0354 .
GeneIDi 7146850.
KEGGi eck:EC55989_0354.
PATRICi 38474058. VBIEscCol113220_0362.

Phylogenomic databases

eggNOGi COG0654.
HOGENOMi HOG000221401.
KOi K05712.
OMAi RNRISAW.
OrthoDBi EOG63RGN4.

Enzyme and pathway databases

UniPathwayi UPA00714 .
BioCyci ECOL585055:GJOM-361-MONOMER.

Family and domain databases

HAMAPi MF_01652. MhpA.
InterProi IPR023786. 3-HPP/3HCI_hydroxylase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 55989 / EAEC.

Entry informationi

Entry nameiMHPA_ECO55
AccessioniPrimary (citable) accession number: B7L503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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