ID   B7L2M3_METC4            Unreviewed;       385 AA.
AC   B7L2M3;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Metal dependent phosphohydrolase {ECO:0000313|EMBL:ACK85067.1};
GN   OrderedLocusNames=Mchl_4291 {ECO:0000313|EMBL:ACK85067.1};
OS   Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS   extorquens).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=440085 {ECO:0000313|EMBL:ACK85067.1, ECO:0000313|Proteomes:UP000002385};
RN   [1] {ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT   CM4.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACK85067.1, ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RX   PubMed=22887658; DOI=10.1128/JB.01009-12;
RA   Marx C.J., Bringel F., Chistoserdova L., Moulin L., Farhan Ul Haque M.,
RA   Fleischman D.E., Gruffaz C., Jourand P., Knief C., Lee M.C., Muller E.E.,
RA   Nadalig T., Peyraud R., Roselli S., Russ L., Goodwin L.A., Ivanova N.,
RA   Kyrpides N., Lajus A., Land M.L., Medigue C., Mikhailova N., Nolan M.,
RA   Woyke T., Stolyar S., Vorholt J.A., Vuilleumier S.;
RT   "Complete genome sequences of six strains of the genus Methylobacterium.";
RL   J. Bacteriol. 194:4746-4748(2012).
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DR   EMBL; CP001298; ACK85067.1; -; Genomic_DNA.
DR   RefSeq; WP_015952190.1; NC_011757.1.
DR   AlphaFoldDB; B7L2M3; -.
DR   KEGG; mch:Mchl_4291; -.
DR   HOGENOM; CLU_000445_92_10_5; -.
DR   Proteomes; UP000002385; Chromosome.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:UniProt.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR006675; HDIG_dom.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ACK85067.1}.
FT   DOMAIN          188..383
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          210..333
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   385 AA;  41761 MW;  8EFA057EF705DE71 CRC64;
     MQEPRDRHER QGVQREDVVV LVSDRRERAE RLARGIALVL PCRVVEPGAA LPADRPIAFV
     VDLATDLAAD RGSAWIMWLA ERIRESGLPC LYLARGNAVQ DTAAVRLLGT PTVIDPRQSA
     GIVPTLIRLV AEGKARGGSS DKARKPGGVS PELRVERATT LVTRLFDKAA TGRPPSPEEA
     EEGTRIVLDT VSEVGIRTWL DLVWRHDIQV YQHSLSVAGF AAAFAAELGF SRGDRQRLAK
     AALLHDVGKA LIPHAILNKP GPLTPDEMTV MRTHAALGAD LLAQEAAFEP EILDVVRYHH
     ERLDGSGYPE GLKGARISDL VRLVAICDVH SALTERRVYR PPLPAAEAAA IMQAQAGQLD
     PDLLRVYRPI IFRAGDAAGG PSVRS
//