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B7KUA6 (B7KUA6_METC4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Mchl_1748
OrganismMethylobacterium chloromethanicum (strain CM4 / NCIMB 13688) [Complete proteome] [HAMAP] EMBL ACK82611.1
Taxonomic identifier440085 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ACK82611.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2261Iron By similarity HAMAP MF_00323
Metal binding3071Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
B7KUA6 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 63FDEAB40FA1DA7F

FASTA35640,562
        10         20         30         40         50         60 
MNERVEPHTL LRDPVPVAPT ALPPDHPAVR TGRVGVLLMN LGTPEGTSYW PMRRYLKEFL 

        70         80         90        100        110        120 
SDRRVIEVPR LIWWPLLNLI ILTKRPGPKG RDYASIWNNE RDEGPLKTIT RGQCEKLQAA 

       130        140        150        160        170        180 
MGDSVVVDWA MRYGKPEVSL RIQALLDQGC DRILLVPLYP QYAAATSATA CDQAFKALMQ 

       190        200        210        220        230        240 
MRWQPTVRVS PPYHDDPVYI EAMAQSIREG LAKLDFEPEV ILTSFHGVPK SYLLKGDPYH 

       250        260        270        280        290        300 
CQCLKTGRLI REAMGYTPER MRVTFQSRFG NEEWLKPYTD ETVQALAKSG VKRMAIVAPG 

       310        320        330        340        350 
FTADCLETLE ELDGENRHYF EENGGEKYAF IPCLNDSDLG MRVIENVVRR ELQGWI

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium chloromethanicum CM4."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Marx C., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CM4 / NCIMB 13688.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001298 Genomic DNA. Translation: ACK82611.1.
RefSeqYP_002420539.1. NC_011757.1.

3D structure databases

ProteinModelPortalB7KUA6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7KUA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7114543.
GenomeReviewsGene locus Mchl_1748 in contig CP001298_GR.
KEGGmch:Mchl_1748.
PATRIC22497675. VBIMetChl132133_1677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK979865.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7KUA6_METC4
AccessionPrimary (citable) accession number: B7KUA6
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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