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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Methylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMEXT440085:G1GUD-3314-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Mchl_3294
OrganismiMethylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
Taxonomic identifieri440085 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000002385 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001191591 – 368S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST368

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

SMRiB7KTS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004402
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

B7KTS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDLFDFEL PEAAIALRPA SPRDASRLLV VRPGDPLADR GVRDLPALLS
60 70 80 90 100
PGDALVFNDT RVIPARLSGI RHRAGGSGQR CEAMLHLREA PDRWRAFARP
110 120 130 140 150
AKRLAPGDRI RFGSEGASEV CALSGLDATV EERGEGGEIL LRFDLSGPAL
160 170 180 190 200
DEAIAGLGAL PLPPYIAGKR PTDAQDTTDY QTVYAREPGA VAAPTAGLHF
210 220 230 240 250
SDALLAGIDA AGIERVHVTL HVGAGTFLPV KADDTDAHRM HAEIGILDAA
260 270 280 290 300
TAARLNAVRA RGNRVVAVGT TALRLLESAA DPDGTIRPFS GATDIFITPG
310 320 330 340 350
YRFRAVDALV TNFHLPRSTL FMLVSAFAGL DTMRAAYAHA IQSGYRFYSY
360
GDASLLFPEG APVSESIT
Length:368
Mass (Da):39,110
Last modified:February 10, 2009 - v1
Checksum:i47CD0559B426753A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001298 Genomic DNA Translation: ACK84131.1
RefSeqiWP_015951447.1, NC_011757.1

Genome annotation databases

EnsemblBacteriaiACK84131; ACK84131; Mchl_3294
KEGGimch:Mchl_3294

Similar proteinsi

Entry informationi

Entry nameiQUEA_METC4
AccessioniPrimary (citable) accession number: B7KTS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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