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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei224SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Binding sitei229NADUniRule annotation1
Binding sitei281NADUniRule annotation1
Binding sitei316NADUniRule annotation1
Binding sitei382NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 197NADUniRule annotation3
Nucleotide bindingi258 – 263NADUniRule annotation6
Nucleotide bindingi337 – 339NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Mchl_4897
OrganismiMethylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
Taxonomic identifieri440085 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000002385 Componenti: Chromosome

Subcellular locationi

B7KSJ4:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001966701 – 468AdenosylhomocysteinaseAdd BLAST468

Structurei

3D structure databases

ProteinModelPortaliB7KSJ4.
SMRiB7KSJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B7KSJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVANDYIVK DIGLADYGRK EISIAETEMP GLMSTRAEYG ASQPLKGAKI
60 70 80 90 100
AGSLHMTIQT AVLIETLKAL GADIRWVSCN IYSTQDHAAA AIAAAGIPVF
110 120 130 140 150
AVKGETLTEY WDYTSKLFDW HDGGMPNMIL DDGGDATMFV HLGLRAENGD
160 170 180 190 200
TAFLDKPESE EEEVFFALLK KKLAEKPKGW FAGLADSIKG VSEETTTGVH
210 220 230 240 250
RLYNLAKEGK LLFPAINVND SVTKSKFDNL YGCKESLVDG IRRGTDVMMA
260 270 280 290 300
GKVAMVAGFG DVGKGSAASL RNAGCRVLVS EIDPICALQA AMEGYEVVTM
310 320 330 340 350
EDAAPRADIF VTATGNKDII TIEHMRAMKD RAIVCNIGHF DNEIQVAGLK
360 370 380 390 400
NLKWQNIKPQ VDEIEFADGH RIILLSEGRL VNLGNATGHP SFVMSASFTN
410 420 430 440 450
QTLAQIELWT NPGKYERQVY TLPKALDEKV AALHLEKIGV KLSKLRPDQA
460
AYIGVSQTGP FKPEHYRY
Length:468
Mass (Da):51,024
Last modified:February 10, 2009 - v1
Checksum:iEC7463AF4D3425D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001298 Genomic DNA. Translation: ACK85662.1.
RefSeqiWP_003606448.1. NC_011757.1.

Genome annotation databases

EnsemblBacteriaiACK85662; ACK85662; Mchl_4897.
KEGGimch:Mchl_4897.

Similar proteinsi

Entry informationi

Entry nameiSAHH_METC4
AccessioniPrimary (citable) accession number: B7KSJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families