ID   B7KQL5_METC4            Unreviewed;      1088 AA.
AC   B7KQL5;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Maltokinase {ECO:0000256|ARBA:ARBA00013882};
DE            EC=2.7.1.175 {ECO:0000256|ARBA:ARBA00011962};
DE            EC=5.4.99.16 {ECO:0000256|ARBA:ARBA00012619};
DE   AltName: Full=Maltose alpha-D-glucosyltransferase {ECO:0000256|ARBA:ARBA00031378};
DE   AltName: Full=Maltose-1-phosphate synthase {ECO:0000256|ARBA:ARBA00031251};
GN   OrderedLocusNames=Mchl_2940 {ECO:0000313|EMBL:ACK83779.1};
OS   Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS   extorquens).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=440085 {ECO:0000313|EMBL:ACK83779.1, ECO:0000313|Proteomes:UP000002385};
RN   [1] {ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT   CM4.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACK83779.1, ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RX   PubMed=22887658; DOI=10.1128/JB.01009-12;
RA   Marx C.J., Bringel F., Chistoserdova L., Moulin L., Farhan Ul Haque M.,
RA   Fleischman D.E., Gruffaz C., Jourand P., Knief C., Lee M.C., Muller E.E.,
RA   Nadalig T., Peyraud R., Roselli S., Russ L., Goodwin L.A., Ivanova N.,
RA   Kyrpides N., Lajus A., Land M.L., Medigue C., Mikhailova N., Nolan M.,
RA   Woyke T., Stolyar S., Vorholt J.A., Vuilleumier S.;
RT   "Complete genome sequences of six strains of the genus Methylobacterium.";
RL   J. Bacteriol. 194:4746-4748(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+);
CC         Xref=Rhea:RHEA:31915, ChEBI:CHEBI:15378, ChEBI:CHEBI:17306,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63576, ChEBI:CHEBI:456216;
CC         EC=2.7.1.175; Evidence={ECO:0000256|ARBA:ARBA00001537};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-maltose = alpha,alpha-trehalose; Xref=Rhea:RHEA:15145,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17306; EC=5.4.99.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001595};
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000256|ARBA:ARBA00006219}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family. TreS
CC       subfamily. {ECO:0000256|ARBA:ARBA00005496}.
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DR   EMBL; CP001298; ACK83779.1; -; Genomic_DNA.
DR   RefSeq; WP_015951201.1; NC_011757.1.
DR   AlphaFoldDB; B7KQL5; -.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   KEGG; mch:Mchl_2940; -.
DR   HOGENOM; CLU_007635_1_1_5; -.
DR   Proteomes; UP000002385; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0047471; F:maltose alpha-D-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd11334; AmyAc_TreS; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR040999; Mak_N_cap.
DR   InterPro; IPR032091; Malt_amylase_C.
DR   InterPro; IPR045857; O16G_dom_2.
DR   InterPro; IPR012810; TreS/a-amylase_N.
DR   InterPro; IPR012811; TreS_maltokin_C_dom.
DR   NCBIfam; TIGR02457; TreS_Cterm; 1.
DR   NCBIfam; TIGR02456; treS_nterm; 1.
DR   PANTHER; PTHR10357; ALPHA-AMYLASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR10357:SF219; MALTOSE ALPHA-D-GLUCOSYLTRANSFERASE; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   Pfam; PF01636; APH; 1.
DR   Pfam; PF18085; Mak_N_cap; 1.
DR   Pfam; PF16657; Malt_amylase_C; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT   DOMAIN          17..411
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   1088 AA;  122104 MW;  5A82AB8B73873E72 CRC64;
     MIDRSDPQWY RDAIIYQIHV KSFFDSSNDG IGDFEGLTQK LDYVRDLGVT AIWLMPFYPS
     PLRDDGYDIA DYRDVNPSYG TMEDFRRFVA AAHERGLRVI TELVINHTSD QHPWFQRARE
     APAGSPERDF YVWSDTDEKY SDTRIIFLDT EVSNWTWDPV AKQYFWHRFY SHQPDLNFDN
     PAVLEAVIEV MRYWLDMGVD GLRLDAIPYL IERDGTNCEN LSETHDVIKA IRAALDAEYP
     DRMLLAEANQ WPEETAQYFG EGDECHMAFH FPLMPRMYMA IAREDRHPIT DIMRQTPEIP
     EGCQWAIFLR NHDELTLEMV TAEERDYLWS FYAAERRARI NLGIRRRLAP LLENDRRKIE
     LMKSLVLSMP GTPVLYYGDE IGMGDNIYLG DRDGVRTPMQ WSPDRNGGFS RATPQKLFLP
     SIQDPIYGYD AINVEAQIQA QTSLLNWTRR MIAIRNNSVA LGRGAIQFLY PANRKVLAWI
     REHENERILC VANLSRAPQA VQLDLSDLRG AIPIELTGGT AFPAIGELPY LLTLPAYGFY
     WFALSVANTG EIGPQPQSPE LFTLVLTGGI ETLIKGRERT AFERTVAPPF IASRRWFGAK
     GTRIKSVQVD DSAIVKDGSG EGKFLLPRVA VTLANGERQD YFVPLAVEEG REDETLLGHA
     VARVRRGPRT GLLYEAAAAA PFAVALIEAM RDGVTIPSER GSLVFSTTSA YDPEVPFEAA
     DVRRLSAEQS NTSIAIGARM MLKLLRRLQP GTHPEIEIGR FLTEQAHFAN TPALLGVVEH
     VAADGTRTAL ALLQKFVLNQ GDAWTLMLEG LRRDFETVVL APESEAPAPE DAFNAHLRWA
     ELLGQRTAEL HRAFAIDTDD PAFAVEPFDE ADLASLADDA RHQAARAFKG LDAITAWSPG
     SASEALASRR SEVEALITDL ASGPLRGATK TRIHGDYHLG QVLASEGDLI IVDFEGEPSR
     PVEQRRAKST PMRDVAGMLR SFAYGAETVV REITARFGDS EERARNAAIA WRGMIDAAFL
     DGYGQAVAGS RAAVEDAETQ SRLLRLSLLT KALYEVDYEV NNRPDWIEIP ARGVLNILDE
     AKRDRASV
//