ID   B7KQ94_METC4            Unreviewed;       571 AA.
AC   B7KQ94;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=Mchl_1244 {ECO:0000313|EMBL:ACK82130.1};
OS   Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS   extorquens).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=440085 {ECO:0000313|EMBL:ACK82130.1, ECO:0000313|Proteomes:UP000002385};
RN   [1] {ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT   CM4.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACK82130.1, ECO:0000313|Proteomes:UP000002385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RX   PubMed=22887658; DOI=10.1128/JB.01009-12;
RA   Marx C.J., Bringel F., Chistoserdova L., Moulin L., Farhan Ul Haque M.,
RA   Fleischman D.E., Gruffaz C., Jourand P., Knief C., Lee M.C., Muller E.E.,
RA   Nadalig T., Peyraud R., Roselli S., Russ L., Goodwin L.A., Ivanova N.,
RA   Kyrpides N., Lajus A., Land M.L., Medigue C., Mikhailova N., Nolan M.,
RA   Woyke T., Stolyar S., Vorholt J.A., Vuilleumier S.;
RT   "Complete genome sequences of six strains of the genus Methylobacterium.";
RL   J. Bacteriol. 194:4746-4748(2012).
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DR   EMBL; CP001298; ACK82130.1; -; Genomic_DNA.
DR   RefSeq; WP_015950037.1; NC_011757.1.
DR   AlphaFoldDB; B7KQ94; -.
DR   KEGG; mch:Mchl_1244; -.
DR   HOGENOM; CLU_034273_0_0_5; -.
DR   Proteomes; UP000002385; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00143; PP2Cc; 1.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF13672; PP2C_2; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51746; PPM_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ACK82130.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ACK82130.1};
KW   Transferase {ECO:0000313|EMBL:ACK82130.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        548..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..237
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   DOMAIN          270..532
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   571 AA;  62021 MW;  C97A8FE73EE32DC1 CRC64;
     MPNDLRLTLG QHSAAGRKPH NQDFHGALIP GQPALGLKGA AIAIADGIGS SAVSHVASET
     AVKSFLTDYY DTPDTWSVKS AAQRVIAAAN SWLHAETRRS RHEPDRGYVT TFSALILKGR
     TAHLFHVGDG RICRVAGRSL EQLTEDHRLV LSAEESYLGR ALGAGGRVEI DHASVRTEPG
     DVFVLTTDGV HEHVDPETIA GLIARHADDL DTAACEIVRH AYEAGSTDNL TAQIVRIEAA
     PEDGPADLAG RVADLAPAPL LDPPTDFDGY RVLRTLHASH RSHVYLALDS ETGATVALKV
     PSTEARDDPA QLRRLVMEEW IARRIDSPHV LKAQPQARRR SHLYTAMEYI EGRTLAQWMR
     DNPAPDLETV RSLVEQIARG LQAFHRREMV HQDLRPQNVL IDAAGTVRII DFGATRVAGV
     AELAPEEPVL GTQQYSAPEY LAGHPGTSAA DVFSLGIIAY QMLTGQLPYG AAAARALTEA
     RAQRLRYVPL SAVRPGLPVW IDGALRKAVH PNPALRYEAL SAFTYDLRHP NPSLAGMRRA
     ALMERNPVLF WKLVSLGLGL ALLALLVSRA V
//