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B7KPR9 (B7KPR9_METC4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Mchl_2816
OrganismMethylobacterium chloromethanicum (strain CM4 / NCIMB 13688) [Complete proteome] [HAMAP] EMBL ACK83655.1
Taxonomic identifier440085 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B7KPR9 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 3AE45949197842B9

FASTA34036,865
        10         20         30         40         50         60 
MSADTINLTA DPNRVPHPAV TGDKPPLEIL LCAPRGFCAG VVRAIDVVER ALAIYGAPVY 

        70         80         90        100        110        120 
VRHEIVHNKY VVETLKRKGA VFVRELDEVP DSGAPVIFSA HGVAKTVPQN ADARGLTTID 

       130        140        150        160        170        180 
ATCPLVTKVH REAEIHHKRG RHVLLVGHSG HPEVVGTMGQ LPKGSITLVE DIDQIDALNP 

       190        200        210        220        230        240 
PADQALAWVT QTTLSIDDTK HIVEALKAKF TGIHGPHKDD ICYATTNRQE AVKEVAPRVD 

       250        260        270        280        290        300 
ALIVVGSSNS SNSQRLREVA ERAGCPITRL VLRAEEIDWD AFKDIRRLGL TAGASAPEVL 

       310        320        330        340 
VEEIIDAFAA RFDVTVDQVS VTVEDMSFPL PRELRSEAAE

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium chloromethanicum CM4."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Marx C., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CM4 / NCIMB 13688.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001298 Genomic DNA. Translation: ACK83655.1.
RefSeqYP_002421583.1. NC_011757.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB7KPR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7115045.
GenomeReviewsGene locus Mchl_2816 in contig CP001298_GR.
KEGGmch:Mchl_2816.
PATRIC22499905. VBIMetChl132133_2782.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAWGAPVYV.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB7KPR9_METC4
AccessionPrimary (citable) accession number: B7KPR9
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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