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B7KNQ3

- GLSA_METC4

UniProt

B7KNQ3 - GLSA_METC4

Protein

Glutaminase

Gene

glsA

Organism
Methylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateUniRule annotation
    Binding sitei114 – 1141SubstrateUniRule annotation
    Binding sitei160 – 1601SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Binding sitei243 – 2431SubstrateUniRule annotation
    Binding sitei261 – 2611Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMCHL440085:GCXT-2704-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:Mchl_2652
    OrganismiMethylobacterium extorquens (strain CM4 / NCIMB 13688) (Methylobacterium chloromethanicum)
    Taxonomic identifieri440085 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000002385: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309GlutaminasePRO_1000132907Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi440085.Mchl_2652.

    Structurei

    3D structure databases

    ProteinModelPortaliB7KNQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQRARRIN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7KNQ3-1 [UniParc]FASTAAdd to Basket

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    MPDLESIVKD IAAEMRARPD RGAVASYIPE LARVDAQGFG LVVIDGEGRV    50
    AAGGDADTPF SIQSISKVFT LTLALGMVGD RLWRRVGREP SGSPFNSIVQ 100
    LEREHGIPRN PFINAGAIAV TDLILSGHQP REALGEILRF MQFVAQDDSI 150
    TIDERVAASE KRTGFRNAAL ANYMRSFDVI ENPVDYTLGV YFHHCAIAMT 200
    CRQLATAGLF LAYSGHHPLA GHSVISAERA RRINAIMLTC GHYDGSGDFA 250
    YRVGLPGKSG VGGGILAVAP GKASICVWSP GLDAAGNSHL GRIALEMLVK 300
    RTGWSIFGV 309
    Length:309
    Mass (Da):33,059
    Last modified:February 10, 2009 - v1
    Checksum:iEF4BA77B7AB47E3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001298 Genomic DNA. Translation: ACK83492.1.
    RefSeqiYP_002421420.1. NC_011757.1.

    Genome annotation databases

    EnsemblBacteriaiACK83492; ACK83492; Mchl_2652.
    GeneIDi7117402.
    KEGGimch:Mchl_2652.
    PATRICi22499553. VBIMetChl132133_2609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001298 Genomic DNA. Translation: ACK83492.1 .
    RefSeqi YP_002421420.1. NC_011757.1.

    3D structure databases

    ProteinModelPortali B7KNQ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 440085.Mchl_2652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK83492 ; ACK83492 ; Mchl_2652 .
    GeneIDi 7117402.
    KEGGi mch:Mchl_2652.
    PATRICi 22499553. VBIMetChl132133_2609.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QRARRIN.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci MCHL440085:GCXT-2704-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium chloromethanicum CM4."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Marx C., Richardson P.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CM4 / NCIMB 13688.

    Entry informationi

    Entry nameiGLSA_METC4
    AccessioniPrimary (citable) accession number: B7KNQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3