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B7KL61

- DAPAT_CYAP7

UniProt

B7KL61 - DAPAT_CYAP7

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Protein

LL-diaminopimelate aminotransferase

Gene
dapL, PCC7424_4059
Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei75 – 751Substrate; shared with dimeric partner By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei187 – 1871Pyridoxal phosphate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei215 – 2151Pyridoxal phosphate By similarity
Binding sitei218 – 2181Pyridoxal phosphate By similarity
Binding sitei246 – 2461Pyridoxal phosphate By similarity
Binding sitei248 – 2481Pyridoxal phosphate By similarity
Binding sitei257 – 2571Pyridoxal phosphate By similarity
Binding sitei292 – 2921Substrate; shared with dimeric partner By similarity
Binding sitei388 – 3881Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCSP65393:GJP7-4106-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:PCC7424_4059
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002384: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411LL-diaminopimelate aminotransferaseUniRule annotationPRO_1000186862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi65393.PCC7424_4059.

Structurei

3D structure databases

ProteinModelPortaliB7KL61.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiHAPYVWL.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

Sequencei

Sequence statusi: Complete.

B7KL61-1 [UniParc]FASTAAdd to Basket

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MATINDNYLK LKAGYLFPEI ARRVNAFAEA HPEAKIIKLG IGDVTEPLPQ    50
ACRQAMIKAV EEMGDRATFK GYGPEQGYNW LREKIAQNDF QARGCDIDAS 100
EIFISDGSKC DTGNILDIFG KNNTIAVTDP VYPVYVDTNV MAGHTGDAND 150
KGEYLGLVYL PMTANNNFTP ELPSQKVDLI YLCFPNNPTG ATATKENLTK 200
WVNYAKENGS IIFFDAAYEA FITDPSLPHS IYEIEGARDC AIEFRSFSKN 250
AGFTGTRCAL TVVPKTLKAK ASDGSEVELW KLWNRRQSTK FNGVSYIVQR 300
GAEAVYSEEG QAQVKALVNF YLENAKIICD KLSFAGLTVY GGVNAPYVWV 350
KTPDGLSSWD FFDKLLQSAN VVGTPGSGFG AAGEGYFRIS AFNSRENVEE 400
ATRRIIEKLT V 411
Length:411
Mass (Da):45,272
Last modified:February 10, 2009 - v1
Checksum:i82058D26638A9434
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72433.1.
RefSeqiWP_015956018.1. NC_011729.1.
YP_002379301.1. NC_011729.1.

Genome annotation databases

EnsemblBacteriaiACK72433; ACK72433; PCC7424_4059.
GeneIDi7108977.
KEGGicyc:PCC7424_4059.
PATRICi21557116. VBICyaSp136448_4157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72433.1 .
RefSeqi WP_015956018.1. NC_011729.1.
YP_002379301.1. NC_011729.1.

3D structure databases

ProteinModelPortali B7KL61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 65393.PCC7424_4059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK72433 ; ACK72433 ; PCC7424_4059 .
GeneIDi 7108977.
KEGGi cyc:PCC7424_4059.
PATRICi 21557116. VBICyaSp136448_4157.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223061.
KOi K10206.
OMAi HAPYVWL.
OrthoDBi EOG6XWV2X.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci CSP65393:GJP7-4106-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7424.

Entry informationi

Entry nameiDAPAT_CYAP7
AccessioniPrimary (citable) accession number: B7KL61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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