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B7KL61

- DAPAT_CYAP7

UniProt

B7KL61 - DAPAT_CYAP7

Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
    Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
    Binding sitei75 – 751Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei215 – 2151Pyridoxal phosphateUniRule annotation
    Binding sitei218 – 2181Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei248 – 2481Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei388 – 3881SubstrateUniRule annotation

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCSP65393:GJP7-4106-MONOMER.
    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
    Short name:
    DAP-ATUniRule annotation
    Short name:
    DAP-aminotransferaseUniRule annotation
    Short name:
    LL-DAP-aminotransferaseUniRule annotation
    Gene namesi
    Name:dapLUniRule annotation
    Ordered Locus Names:PCC7424_4059
    OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
    Taxonomic identifieri65393 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002384: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411LL-diaminopimelate aminotransferasePRO_1000186862Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi65393.PCC7424_4059.

    Structurei

    3D structure databases

    ProteinModelPortaliB7KL61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223061.
    KOiK10206.
    OMAiHAPYVWL.
    OrthoDBiEOG6XWV2X.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7KL61-1 [UniParc]FASTAAdd to Basket

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    MATINDNYLK LKAGYLFPEI ARRVNAFAEA HPEAKIIKLG IGDVTEPLPQ    50
    ACRQAMIKAV EEMGDRATFK GYGPEQGYNW LREKIAQNDF QARGCDIDAS 100
    EIFISDGSKC DTGNILDIFG KNNTIAVTDP VYPVYVDTNV MAGHTGDAND 150
    KGEYLGLVYL PMTANNNFTP ELPSQKVDLI YLCFPNNPTG ATATKENLTK 200
    WVNYAKENGS IIFFDAAYEA FITDPSLPHS IYEIEGARDC AIEFRSFSKN 250
    AGFTGTRCAL TVVPKTLKAK ASDGSEVELW KLWNRRQSTK FNGVSYIVQR 300
    GAEAVYSEEG QAQVKALVNF YLENAKIICD KLSFAGLTVY GGVNAPYVWV 350
    KTPDGLSSWD FFDKLLQSAN VVGTPGSGFG AAGEGYFRIS AFNSRENVEE 400
    ATRRIIEKLT V 411
    Length:411
    Mass (Da):45,272
    Last modified:February 10, 2009 - v1
    Checksum:i82058D26638A9434
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK72433.1.
    RefSeqiWP_015956018.1. NC_011729.1.
    YP_002379301.1. NC_011729.1.

    Genome annotation databases

    EnsemblBacteriaiACK72433; ACK72433; PCC7424_4059.
    GeneIDi7108977.
    KEGGicyc:PCC7424_4059.
    PATRICi21557116. VBICyaSp136448_4157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK72433.1 .
    RefSeqi WP_015956018.1. NC_011729.1.
    YP_002379301.1. NC_011729.1.

    3D structure databases

    ProteinModelPortali B7KL61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 65393.PCC7424_4059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK72433 ; ACK72433 ; PCC7424_4059 .
    GeneIDi 7108977.
    KEGGi cyc:PCC7424_4059.
    PATRICi 21557116. VBICyaSp136448_4157.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223061.
    KOi K10206.
    OMAi HAPYVWL.
    OrthoDBi EOG6XWV2X.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .
    BioCyci CSP65393:GJP7-4106-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7424.

    Entry informationi

    Entry nameiDAPAT_CYAP7
    AccessioniPrimary (citable) accession number: B7KL61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3