ID   B7KJT7_GLOC7            Unreviewed;       812 AA.
AC   B7KJT7;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ACK69536.1};
GN   OrderedLocusNames=PCC7424_1083 {ECO:0000313|EMBL:ACK69536.1};
OS   Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC
OS   7424)).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Aphanothecaceae; Gloeothece; Gloeothece citriformis.
OX   NCBI_TaxID=65393 {ECO:0000313|EMBL:ACK69536.1, ECO:0000313|Proteomes:UP000002384};
RN   [1] {ECO:0000313|Proteomes:UP000002384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7424 {ECO:0000313|Proteomes:UP000002384};
RX   PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
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DR   EMBL; CP001291; ACK69536.1; -; Genomic_DNA.
DR   RefSeq; WP_012598482.1; NC_011729.1.
DR   AlphaFoldDB; B7KJT7; -.
DR   STRING; 65393.PCC7424_1083; -.
DR   KEGG; cyc:PCC7424_1083; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_20_3; -.
DR   OrthoDB; 9787983at2; -.
DR   Proteomes; UP000002384; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR038318; KdpD_sf.
DR   InterPro; IPR025201; KdpD_TM.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF13493; DUF4118; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF13426; PAS_9; 2.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002384};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          126..199
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          201..253
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          257..302
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          329..381
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          414..546
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          555..811
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   812 AA;  92754 MW;  8713A012FFE7379B CRC64;
     MRQNFKPLKI PPYSLAIICP LLALGVRYLL NWALGNNAPL LIFIIPVIIT AWYGGLLPGI
     LSTVISAYLG NYFFIHPTEQ FKILSLPETV RIIIFLSEGI FLSIFFEYYK RLNTKTSQIV
     ESLRESEERY RLLVEGIEDY GIFMLDGQGR IISWNLGAER IQGYQSTEII GRHYSIFFTT
     TDTSAKVPEK ILQTALKQGR FKGEGWRRRK DGSLFWASIV LSPVFAQNRQ LKGFAKITRD
     ISERKQAEVQ KNKLLKDLTD LKLALDQSAI VAVTNSQGII TAVNDQFCQI SGYSKEELIG
     KTHRIINSGY HSKKFFQQLW ATISQGKIWR GEICNRSKTG QFYWVATTIV PFLNQNNQPF
     QYFAIRFDIT QRKLAEKRLR HEVLHDSLTG LPNRTLLIQR LEQVRHRAKR KANYCFALLF
     IDLDRFKNIN DNLGHPIGDR VLITIASRLQ ECVRSLDTVA RLGGDEFIIL LDELEEEKEI
     FKIIERIEKQ LTTPMVIEGQ TLSLTASIGI AFNDTNLSNS DLLRNADLAM YRVKNEGKAG
     YAIYQSEMYA QAQALWELEN HLKLAIERQE FLLYYQPILS LKTLTVIGFE ALIRWQHPQR
     GLISPVHFIP VAEETDLIVA IGEWVLQQSC QQLSAWREKY PQANHLTINV NLSNRQLEKD
     NFVYKLDNVL QQTGLPATQL KLEITETLLM TNLAAAIATL SQLKQRNINI SIDDFGTGYS
     SLNYLCRLPV SSLKIDRSFV ANVHEDSKNL QIIQTILSLG EQLMIEVIAE GIETQKHLEQ
     LQELGCQYGQ GYLFSKPVNC EAAEQLICAG LC
//