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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCSP65393:G1GUC-867-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:PCC7424_0883
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesCyanothecaceaeCyanothece
Proteomesi
  • UP000002384 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001184741 – 334Methionyl-tRNA formyltransferaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi65393.PCC7424_0883

Structurei

3D structure databases

ProteinModelPortaliB7KHD0
SMRiB7KHD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 114Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B7KHD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVFFGTPQ FAVPSLERLL EHSDIDVVAV VTQPDKPRGR GKQLIPSPIK
60 70 80 90 100
KVALDHQIPI WQPKRVKKNA QTLTKLRETN ADAFAVVAYG QILSAEILQM
110 120 130 140 150
PKLACINVHG SILPKYRGAA PIQWSIYHGE TQTGITTMLM DEGMDTGAML
160 170 180 190 200
LKAYTPIQLL DNADKIATTL ANQGADLLIE TLLKLEQGEL NPESQNSELA
210 220 230 240 250
TYAPLIQKED YLINWTRHAL QIHNQVRGFY PNCFTTFREQ PLKILATAPL
260 270 280 290 300
GEAYWEHLPS NIAQKIQPQW TTLSSLTSSP GEVVNLIKNL GPIVQTGEGL
310 320 330
LLLLQVQLSG KRPQSGWDFV NGTRLSVGEK FLMV
Length:334
Mass (Da):37,077
Last modified:February 10, 2009 - v1
Checksum:iFFAF6174CA9D4A30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001291 Genomic DNA Translation: ACK69339.1
RefSeqiWP_012598286.1, NC_011729.1

Genome annotation databases

EnsemblBacteriaiACK69339; ACK69339; PCC7424_0883
KEGGicyc:PCC7424_0883

Similar proteinsi

Entry informationi

Entry nameiFMT_CYAP7
AccessioniPrimary (citable) accession number: B7KHD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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