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B7KGS0

- PUR9_CYAP7

UniProt

B7KGS0 - PUR9_CYAP7

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCSP65393:GJP7-3653-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:PCC7424_3609
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002384: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Bifunctional purine biosynthesis protein PurHPRO_1000117868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi65393.PCC7424_3609.

Structurei

3D structure databases

ProteinModelPortaliB7KGS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B7KGS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRLVLLSVS DKTGLIELAR QLVEEFEFEI ISSGGTAKSL QDAGIPVIKV
60 70 80 90 100
GDYTGSPEIL GGRVKTLHPR IHGGILARRD VPQDLKDLDA NNIRPLDLVV
110 120 130 140 150
VNLYPFEQTI AKDNVTVAQA IEQIDIGGPA MLRATAKNFA HLTVLCNPKY
160 170 180 190 200
YQPYLEELRQ HNGETSLAFR QKMAGETFAL TNAYDQAIAS YFASLTPEAT
210 220 230 240 250
ENPLPTRFSV AGLELQSLRY GENPHQSASW YQSGTQPTGW TAATKLQGKE
260 270 280 290 300
LSYNNLVDLE AARRIIVEFD RSEPSCAILK HTNPCGVAVG TTLAEAYNKA
310 320 330 340 350
FNADSMSAFG GIVALNQPID PETAKALTKT FLECVVAPGC DEEAQKILSA
360 370 380 390 400
KSNVRVLILP DLRSGPKQTV KVIAGGLLVQ ASDDALDNPE TWQVVTEKQP
410 420 430 440 450
TPEMMAELLF GWKVAKHVKS NAIVVSKNRT TLGVGAGQMN RVGSVKIALE
460 470 480 490 500
TAGEAAKGGY LASDGFFPFD DSVRTAAAAG ITGIIQPGGS LKDKDSIKAA
510
NELGLVMVLT GMRHFLH
Length:517
Mass (Da):55,629
Last modified:February 10, 2009 - v1
Checksum:i5A8E1503C17807A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK71997.1.
RefSeqiWP_015955590.1. NC_011729.1.
YP_002378865.1. NC_011729.1.

Genome annotation databases

EnsemblBacteriaiACK71997; ACK71997; PCC7424_3609.
GeneIDi7107483.
KEGGicyc:PCC7424_3609.
PATRICi21556208. VBICyaSp136448_3705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK71997.1 .
RefSeqi WP_015955590.1. NC_011729.1.
YP_002378865.1. NC_011729.1.

3D structure databases

ProteinModelPortali B7KGS0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 65393.PCC7424_3609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK71997 ; ACK71997 ; PCC7424_3609 .
GeneIDi 7107483.
KEGGi cyc:PCC7424_3609.
PATRICi 21556208. VBICyaSp136448_3705.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CSP65393:GJP7-3653-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7424.

Entry informationi

Entry nameiPUR9_CYAP7
AccessioniPrimary (citable) accession number: B7KGS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3