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B7KFS1

- LPXB_CYAP7

UniProt

B7KFS1 - LPXB_CYAP7

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCSP65393:GJP7-5099-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PCC7424_5044
    OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
    Taxonomic identifieri65393 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002384: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Lipid-A-disaccharide synthasePRO_1000191472Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi65393.PCC7424_5044.

    Structurei

    3D structure databases

    ProteinModelPortaliB7KFS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7KFS1-1 [UniParc]FASTAAdd to Basket

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    MRIFISTGEV SGDLQGAMLI EALKRQAALK AMDLEIVALG GDRMAETGVS    50
    LLGKTPKIAS IGLIEALPFI MPTWKLQRKA KQYLQENPPD LLILIDYCGP 100
    NVAIGKYARK NIPQVPILYY IAPQAWVWTT NKKTTQDLVN ITDHLLAIFS 150
    EEARYFAQKG MSVSWVGHPI LDRMAQAPTR EEARQKLGIK PDQTAIALLP 200
    VSRKQELKYL LPVVCQAAQQ IQEKLPDVQF LIPLALEDYR STISAMMEEY 250
    GLQGTILDGK SLDALAAADL AIAKSGTVNL ELALLNVPQV VVYRLTPLTL 300
    WIAQNILKFS VPFLSPVNLV VMEEVVPELF QERATPEQIV QESLDLLLNP 350
    QRRQKTLSDY QRVREELGEV GVCDRAAQEI LDYV 384
    Length:384
    Mass (Da):42,842
    Last modified:February 10, 2009 - v1
    Checksum:i8EEF0A16CFEC0BA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK73396.1.
    RefSeqiWP_015956976.1. NC_011729.1.
    YP_002380264.1. NC_011729.1.

    Genome annotation databases

    EnsemblBacteriaiACK73396; ACK73396; PCC7424_5044.
    GeneIDi7107190.
    KEGGicyc:PCC7424_5044.
    PATRICi21559122. VBICyaSp136448_5153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK73396.1 .
    RefSeqi WP_015956976.1. NC_011729.1.
    YP_002380264.1. NC_011729.1.

    3D structure databases

    ProteinModelPortali B7KFS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 65393.PCC7424_5044.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK73396 ; ACK73396 ; PCC7424_5044 .
    GeneIDi 7107190.
    KEGGi cyc:PCC7424_5044.
    PATRICi 21559122. VBICyaSp136448_5153.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CSP65393:GJP7-5099-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7424.

    Entry informationi

    Entry nameiLPXB_CYAP7
    AccessioniPrimary (citable) accession number: B7KFS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3