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B7KFS1

- LPXB_CYAP7

UniProt

B7KFS1 - LPXB_CYAP7

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCSP65393:GJP7-5099-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PCC7424_5044
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002384: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthasePRO_1000191472Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi65393.PCC7424_5044.

Structurei

3D structure databases

ProteinModelPortaliB7KFS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B7KFS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIFISTGEV SGDLQGAMLI EALKRQAALK AMDLEIVALG GDRMAETGVS
60 70 80 90 100
LLGKTPKIAS IGLIEALPFI MPTWKLQRKA KQYLQENPPD LLILIDYCGP
110 120 130 140 150
NVAIGKYARK NIPQVPILYY IAPQAWVWTT NKKTTQDLVN ITDHLLAIFS
160 170 180 190 200
EEARYFAQKG MSVSWVGHPI LDRMAQAPTR EEARQKLGIK PDQTAIALLP
210 220 230 240 250
VSRKQELKYL LPVVCQAAQQ IQEKLPDVQF LIPLALEDYR STISAMMEEY
260 270 280 290 300
GLQGTILDGK SLDALAAADL AIAKSGTVNL ELALLNVPQV VVYRLTPLTL
310 320 330 340 350
WIAQNILKFS VPFLSPVNLV VMEEVVPELF QERATPEQIV QESLDLLLNP
360 370 380
QRRQKTLSDY QRVREELGEV GVCDRAAQEI LDYV
Length:384
Mass (Da):42,842
Last modified:February 10, 2009 - v1
Checksum:i8EEF0A16CFEC0BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001291 Genomic DNA. Translation: ACK73396.1.
RefSeqiWP_015956976.1. NC_011729.1.
YP_002380264.1. NC_011729.1.

Genome annotation databases

EnsemblBacteriaiACK73396; ACK73396; PCC7424_5044.
GeneIDi7107190.
KEGGicyc:PCC7424_5044.
PATRICi21559122. VBICyaSp136448_5153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001291 Genomic DNA. Translation: ACK73396.1 .
RefSeqi WP_015956976.1. NC_011729.1.
YP_002380264.1. NC_011729.1.

3D structure databases

ProteinModelPortali B7KFS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 65393.PCC7424_5044.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK73396 ; ACK73396 ; PCC7424_5044 .
GeneIDi 7107190.
KEGGi cyc:PCC7424_5044.
PATRICi 21559122. VBICyaSp136448_5153.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CSP65393:GJP7-5099-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7424.

Entry informationi

Entry nameiLPXB_CYAP7
AccessioniPrimary (citable) accession number: B7KFS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3