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B7KCI7

- SYL_CYAP7

UniProt

B7KCI7 - SYL_CYAP7

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei618 – 6181ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP65393:GJP7-1882-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PCC7424_1860
    OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
    Taxonomic identifieri65393 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002384: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 854854Leucine--tRNA ligasePRO_1000199189Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi65393.PCC7424_1860.

    Structurei

    3D structure databases

    ProteinModelPortaliB7KCI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi615 – 6195"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7KCI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVYNAEAI EKKWQQTWVE MGLDQTPEDN TKPKYYALSM FPYPSGNLHM    50
    GHVRNYVITD VIARLKRMQG HRVLHPMGWD AFGLPAENAA IERGIHPAKW 100
    TYQNIAQMRQ QLQQLGLSID WSREVTTCSP DYYQWTQWLF LQFFQAGLAY 150
    QKEAAVNWDP VDQTVLANEQ VDSEGKSWRS GAKVERKMLR QWFLKITDYA 200
    EQLLNDLDKL PGWPEKVKLM QANWIGKSIG AYLEFPIVGM DEKIAVFTTR 250
    PDTVYGVTYV VLAPEHPLTP KVTTAKNKKA VEKFIKEVTS ESEQERTAED 300
    KPKKGILTGG KAINPFNGQE VPILIANYVL YEYGTGAVMG VPAHDIRDFK 350
    FAQENKLPIR VVIVPEDQQD QDVTLTQAYT EPGIMVNSGS FDGMDSITGK 400
    TAIIDYAEKQ GFGKARVQYR LRDWLISRQR YWGCPIPVIH CPSCGTVPVP 450
    DEDLPVKLPE DVEFSGRGAS PLAKLDSWIN VPCPSCGEPA KRETDTMDTF 500
    IDSSWYFLRY TDANDQQTAF SLDKVNDWMS VDQYVGGVEH AILHLLYSRF 550
    FTKVVRDRGL VDVDEPFQRL LTQGMVQGMT YKNPKTGKYI PSSQVNPEDP 600
    KDPETGEPLS VFYEKMSKSK YNGVDPKQVL AKYGADTARM FILFKAPPEK 650
    DLEWDDADVE GQFRFLNKVW RIVGEYQSNH KSSSKKKGSL TKVEKDLRRA 700
    IHIAIKEITE DLDGEYQFNT AVSELMKLSN ALVDAKCYES PVYTEGVQTL 750
    LILLAPFAPH IAEELWHTLG HSESVHLQGW PQLDPSALEV DEITLVIQIM 800
    GKTRGTIQVP SSATKEELEK FAFESEVAQR HLKDQEVKKV IVVPGKLVNF 850
    VVGK 854
    Length:854
    Mass (Da):96,892
    Last modified:February 10, 2009 - v1
    Checksum:iE7E26E0AA0BBCC43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK70292.1.
    RefSeqiWP_012599235.1. NC_011729.1.
    YP_002377160.1. NC_011729.1.

    Genome annotation databases

    EnsemblBacteriaiACK70292; ACK70292; PCC7424_1860.
    GeneIDi7109861.
    KEGGicyc:PCC7424_1860.
    PATRICi21552570. VBICyaSp136448_1907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK70292.1 .
    RefSeqi WP_012599235.1. NC_011729.1.
    YP_002377160.1. NC_011729.1.

    3D structure databases

    ProteinModelPortali B7KCI7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 65393.PCC7424_1860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK70292 ; ACK70292 ; PCC7424_1860 .
    GeneIDi 7109861.
    KEGGi cyc:PCC7424_1860.
    PATRICi 21552570. VBICyaSp136448_1907.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSP65393:GJP7-1882-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7424.

    Entry informationi

    Entry nameiSYL_CYAP7
    AccessioniPrimary (citable) accession number: B7KCI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3