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B7KAA8

- PDXA_CYAP7

UniProt

B7KAA8 - PDXA_CYAP7

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, PCC7424_4519
Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Substrate By similarity
Metal bindingi170 – 1701Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi215 – 2151Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi282 – 2821Divalent metal cation; shared with dimeric partner By similarity
Binding sitei290 – 2901Substrate By similarity
Binding sitei299 – 2991Substrate By similarity
Binding sitei308 – 3081Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciCSP65393:GJP7-4569-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:PCC7424_4519
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002384: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3433434-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_1000128240Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi65393.PCC7424_4519.

Structurei

3D structure databases

ProteinModelPortaliB7KAA8.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B7KAA8-1 [UniParc]FASTAAdd to Basket

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MKSLALTLGD PAGIGSEVIL KALADPSVGE NYNITVVGSR SLLEESYHQL    50
RSLPHVNHSD LVDPANLLIL DIPLDKTTKS QIQLGKGNAA SGEASFTYLQ 100
AAIAGTLKGE FAGIVTAPIA KSCWKAAGYH YPGQTEVLAQ AAGVEKFGML 150
FVARSPYTGW MLRTLLATTH IPLSQVPTVL TPELMTLKLE LLIDCLKNDF 200
RLDHPKIAIA GLNPHSGEQG QLGTEERDWL TPWLEEEKKR HCEVELVGLV 250
PPDTMWVTPG QAWYGNAPHP QHGADGYLAL YHDQGLIPVK LMAFDQAINT 300
TIGLPFIRTS PDHGTAFDIA GKGIARPASM IEAIKLAQAL VNG 343
Length:343
Mass (Da):36,976
Last modified:February 10, 2009 - v1
Checksum:i9E479E2A31053509
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72882.1.
RefSeqiWP_015956465.1. NC_011729.1.
YP_002379750.1. NC_011729.1.

Genome annotation databases

EnsemblBacteriaiACK72882; ACK72882; PCC7424_4519.
GeneIDi7110385.
KEGGicyc:PCC7424_4519.
PATRICi21558056. VBICyaSp136448_4624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72882.1 .
RefSeqi WP_015956465.1. NC_011729.1.
YP_002379750.1. NC_011729.1.

3D structure databases

ProteinModelPortali B7KAA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 65393.PCC7424_4519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK72882 ; ACK72882 ; PCC7424_4519 .
GeneIDi 7110385.
KEGGi cyc:PCC7424_4519.
PATRICi 21558056. VBICyaSp136448_4624.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci CSP65393:GJP7-4569-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7424.

Entry informationi

Entry nameiPDXA_CYAP7
AccessioniPrimary (citable) accession number: B7KAA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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