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B7K947

- B7K947_CYAP7

UniProt

B7K947 - B7K947_CYAP7

Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei164 – 1641Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei167 – 1671N2-acetyl-L-ornithineUniRule annotation
    Binding sitei315 – 3151N2-acetyl-L-ornithineUniRule annotation
    Binding sitei316 – 3161Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCSP65393:GJP7-4502-MONOMER.
    UniPathwayiUPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Ordered Locus Names:PCC7424_4452Imported
    OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))Imported
    Taxonomic identifieri65393 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002384: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei288 – 2881N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi65393.PCC7424_4452.

    Structurei

    3D structure databases

    ProteinModelPortaliB7K947.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni259 – 2624Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0160.
    HOGENOMiHOG000020206.
    KOiK00823.
    OMAiVMCDFFA.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7K947-1 [UniParc]FASTAAdd to Basket

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    MLNISTSQTL PQVPKLITPL PGKRASELIN RDNAVTSPSY TRDYPLVVAR    50
    GQGCMIEDVD GNVFLDMTAG IAVTATGHCH PQVVEAIQYQ STQLVHMSGT 100
    DFYYAPMVDL AEKLAEKAPF PTPVTGSRAK VFFTNSGAES TECAIKLARY 150
    YTGRSRLIAF LGAFHGRTYG AMSLTGSKRV QRQGFGPLVP GVTHIPYGTH 200
    AGLDDLEEKL FTSIVPPDEV AAIMVEPIQG EGGYLVPEDG FLERIRSICD 250
    RYGILMIVDE VQAGMGRTGK LFAIEHWGIM PDMITLAKGI ASGLPLGAVL 300
    SRPELMTWPP GSHATTFGGN PIACAAGKVT LDLLEGGLME NATQRGEELL 350
    LGLTQLSQRF DRLSLPRGKG LMIGIDLLDR EGNLDPVLRN YVLNEAFYRG 400
    LLLLGCGKAA IRFCPPLVIS GEQIEVALKI LAEILEEVVR R 441
    Length:441
    Mass (Da):47,741
    Last modified:February 10, 2009 - v1
    Checksum:iCD422F6B80D664EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK72816.1.
    RefSeqiWP_015956400.1. NC_011729.1.
    YP_002379684.1. NC_011729.1.

    Genome annotation databases

    EnsemblBacteriaiACK72816; ACK72816; PCC7424_4452.
    GeneIDi7110318.
    KEGGicyc:PCC7424_4452.
    PATRICi21557920. VBICyaSp136448_4556.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK72816.1 .
    RefSeqi WP_015956400.1. NC_011729.1.
    YP_002379684.1. NC_011729.1.

    3D structure databases

    ProteinModelPortali B7K947.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 65393.PCC7424_4452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK72816 ; ACK72816 ; PCC7424_4452 .
    GeneIDi 7110318.
    KEGGi cyc:PCC7424_4452.
    PATRICi 21557920. VBICyaSp136448_4556.

    Phylogenomic databases

    eggNOGi COG0160.
    HOGENOMi HOG000020206.
    KOi K00823.
    OMAi VMCDFFA.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00109 .
    BioCyci CSP65393:GJP7-4502-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7424Imported.

    Entry informationi

    Entry nameiB7K947_CYAP7
    AccessioniPrimary (citable) accession number: B7K947
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3