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B7K947

- B7K947_CYAP7

UniProt

B7K947 - B7K947_CYAP7

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Protein
Acetylornithine aminotransferase
Gene
argD, PCC7424_4452
Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641Pyridoxal phosphate; via carbonyl oxygen By similarityUniRule annotation
Binding sitei167 – 1671N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei315 – 3151N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei316 – 3161Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSP65393:GJP7-4502-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:PCC7424_4452Imported
OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))Imported
Taxonomic identifieri65393 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000002384: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi65393.PCC7424_4452.

Structurei

3D structure databases

ProteinModelPortaliB7K947.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 2624Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK00823.
OMAiVMCDFFA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7K947-1 [UniParc]FASTAAdd to Basket

« Hide

MLNISTSQTL PQVPKLITPL PGKRASELIN RDNAVTSPSY TRDYPLVVAR    50
GQGCMIEDVD GNVFLDMTAG IAVTATGHCH PQVVEAIQYQ STQLVHMSGT 100
DFYYAPMVDL AEKLAEKAPF PTPVTGSRAK VFFTNSGAES TECAIKLARY 150
YTGRSRLIAF LGAFHGRTYG AMSLTGSKRV QRQGFGPLVP GVTHIPYGTH 200
AGLDDLEEKL FTSIVPPDEV AAIMVEPIQG EGGYLVPEDG FLERIRSICD 250
RYGILMIVDE VQAGMGRTGK LFAIEHWGIM PDMITLAKGI ASGLPLGAVL 300
SRPELMTWPP GSHATTFGGN PIACAAGKVT LDLLEGGLME NATQRGEELL 350
LGLTQLSQRF DRLSLPRGKG LMIGIDLLDR EGNLDPVLRN YVLNEAFYRG 400
LLLLGCGKAA IRFCPPLVIS GEQIEVALKI LAEILEEVVR R 441
Length:441
Mass (Da):47,741
Last modified:February 10, 2009 - v1
Checksum:iCD422F6B80D664EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72816.1.
RefSeqiWP_015956400.1. NC_011729.1.
YP_002379684.1. NC_011729.1.

Genome annotation databases

EnsemblBacteriaiACK72816; ACK72816; PCC7424_4452.
GeneIDi7110318.
KEGGicyc:PCC7424_4452.
PATRICi21557920. VBICyaSp136448_4556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001291 Genomic DNA. Translation: ACK72816.1 .
RefSeqi WP_015956400.1. NC_011729.1.
YP_002379684.1. NC_011729.1.

3D structure databases

ProteinModelPortali B7K947.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 65393.PCC7424_4452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK72816 ; ACK72816 ; PCC7424_4452 .
GeneIDi 7110318.
KEGGi cyc:PCC7424_4452.
PATRICi 21557920. VBICyaSp136448_4556.

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020206.
KOi K00823.
OMAi VMCDFFA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci CSP65393:GJP7-4502-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7424.

Entry informationi

Entry nameiB7K947_CYAP7
AccessioniPrimary (citable) accession number: B7K947
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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