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B7K7P3

- RBL_CYAP7

UniProt

B7K7P3 - RBL_CYAP7

Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Cyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Substrate; in homodimeric partnerUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Active sitei172 – 1721Proton acceptorUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Metal bindingi198 – 1981Magnesium; via carbamate groupUniRule annotation
    Metal bindingi200 – 2001MagnesiumUniRule annotation
    Metal bindingi201 – 2011MagnesiumUniRule annotation
    Active sitei291 – 2911Proton acceptorUniRule annotation
    Binding sitei292 – 2921SubstrateUniRule annotation
    Binding sitei324 – 3241SubstrateUniRule annotation
    Sitei331 – 3311Transition state stabilizerUniRule annotation
    Binding sitei376 – 3761SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. monooxygenase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. photorespiration Source: UniProtKB-KW
    2. reductive pentose-phosphate cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Calvin cycle, Carbon dioxide fixation, Photorespiration, Photosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCSP65393:GJP7-1382-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCO large subunitUniRule annotation
    Gene namesi
    Name:cbbLUniRule annotation
    Synonyms:rbcLUniRule annotation
    Ordered Locus Names:PCC7424_1367
    OrganismiCyanothece sp. (strain PCC 7424) (Synechococcus sp. (strain ATCC 29155))
    Taxonomic identifieri65393 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002384: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Ribulose bisphosphate carboxylase large chainPRO_1000142749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981N6-carboxylysineUniRule annotation

    Proteomic databases

    PRIDEiB7K7P3.

    Interactioni

    Subunit structurei

    Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi65393.PCC7424_1367.

    Structurei

    3D structure databases

    ProteinModelPortaliB7K7P3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1850.
    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiFTQDWAS.
    OrthoDBiEOG6ZKXMS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01338. RuBisCO_L_type1.
    InterProiIPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7K7P3-1 [UniParc]FASTAAdd to Basket

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    MVQSKAKAGF QAGVKDYRLT YYTPDYTPKD TDLLACFRVT PQPGVPPEEA    50
    GAAVAAESST GTWTTVWTDG LTDLDRYKGR CYDIEPVPNE DNQYFCFVAY 100
    PLDLFEEGSV TNILTSIVGN VFGFKALRAL RLEDIRFPVA LLKTFQGPPH 150
    GITVERDKLN KYGRPLLGCT IKPKLGLSAK NYGRAVYECL RGGLDFTKDD 200
    ENINSQPFMR WRDRFLFVQE AIEKSQAETN EIKGHYLNVT AGTLEEMMKR 250
    AEFAKEIKTP IIMHDYLTGG FTANTTLARW CRDNGVLLHI HRAMHAVIDR 300
    QKNHGIHFRV LAKCLRMSGG DHLHSGTVVG KLEGERGITM GFVDLMREDY 350
    VEEDRARGIF FTQDWASMPG VMPVASGGIH VWHMPALVEI FGDDSCLQFG 400
    GGTLGHPWGN APGATANRVA LEACIQARNE GRSLAREGNE VIREAARWSP 450
    ELAAACELWK EIKFEFEAMD TL 472
    Length:472
    Mass (Da):52,740
    Last modified:February 10, 2009 - v1
    Checksum:iBCB9C7B95BE45189
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK69811.1.
    RefSeqiWP_012598757.1. NC_011729.1.
    YP_002376679.1. NC_011729.1.

    Genome annotation databases

    EnsemblBacteriaiACK69811; ACK69811; PCC7424_1367.
    GeneIDi7111266.
    KEGGicyc:PCC7424_1367.
    PATRICi21551552. VBICyaSp136448_1405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001291 Genomic DNA. Translation: ACK69811.1 .
    RefSeqi WP_012598757.1. NC_011729.1.
    YP_002376679.1. NC_011729.1.

    3D structure databases

    ProteinModelPortali B7K7P3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 65393.PCC7424_1367.

    Proteomic databases

    PRIDEi B7K7P3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK69811 ; ACK69811 ; PCC7424_1367 .
    GeneIDi 7111266.
    KEGGi cyc:PCC7424_1367.
    PATRICi 21551552. VBICyaSp136448_1405.

    Phylogenomic databases

    eggNOGi COG1850.
    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi FTQDWAS.
    OrthoDBi EOG6ZKXMS.

    Enzyme and pathway databases

    BioCyci CSP65393:GJP7-1382-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01338. RuBisCO_L_type1.
    InterProi IPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7424.

    Entry informationi

    Entry nameiRBL_CYAP7
    AccessioniPrimary (citable) accession number: B7K7P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3