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B7K0I0

- PUR5_CYAP8

UniProt

B7K0I0 - PUR5_CYAP8

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, PCC8801_3499
Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP41431:GHLK-3540-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:PCC8801_3499
OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Taxonomic identifieri41431 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000008204: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000193012Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi41431.PCC8801_3499.

Structurei

3D structure databases

ProteinModelPortaliB7K0I0.
SMRiB7K0I0. Positions 11-336.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B7K0I0-1 [UniParc]FASTAAdd to Basket

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MDYREAGVDI QAGRSFVEKI RQGVESTYRR EVLGGLGGFG GYFELPQGYQ    50
HPVLVSGTDG VGTKLKIAQA LNQHHTIGID LVAMCVNDVL TCGAEPLFFL 100
DYLATGKLNP QQLSDVVQGI VEGCRLSGCA LLGGETAEMP GFYPVGEYDV 150
AGFCVGIVEK SKILDGSQVN IGDIAIGLAS SGVHSNGFSL VRKIVEVNGL 200
NWSDRPQLLN GQTLGEVLLT PTQLYVKPIL NALNSGLDIH AMAHITGGGL 250
PENLPRCLDK GQSVEIIDKS WNILPIFQWI AQQGQISPAS MYETFNMGIG 300
FVVIVPPEKA QLAVNFLENQ GILAYEIGKV IEGKGEVVIE SND 343
Length:343
Mass (Da):36,758
Last modified:February 10, 2009 - v1
Checksum:i4ABD4A2ADB109705
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67464.1.
RefSeqiWP_012596723.1. NC_011726.1.
YP_002373620.1. NC_011726.1.

Genome annotation databases

EnsemblBacteriaiACK67464; ACK67464; PCC8801_3499.
GeneIDi7102610.
KEGGicyp:PCC8801_3499.
PATRICi21579363. VBICyaSp125535_3686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67464.1 .
RefSeqi WP_012596723.1. NC_011726.1.
YP_002373620.1. NC_011726.1.

3D structure databases

ProteinModelPortali B7K0I0.
SMRi B7K0I0. Positions 11-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41431.PCC8801_3499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK67464 ; ACK67464 ; PCC8801_3499 .
GeneIDi 7102610.
KEGGi cyp:PCC8801_3499.
PATRICi 21579363. VBICyaSp125535_3686.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CSP41431:GHLK-3540-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8801.

Entry informationi

Entry nameiPUR5_CYAP8
AccessioniPrimary (citable) accession number: B7K0I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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