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B7K0I0

- PUR5_CYAP8

UniProt

B7K0I0 - PUR5_CYAP8

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP41431:GHLK-3540-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:PCC8801_3499
    OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
    Taxonomic identifieri41431 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000008204: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193012Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi41431.PCC8801_3499.

    Structurei

    3D structure databases

    ProteinModelPortaliB7K0I0.
    SMRiB7K0I0. Positions 11-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7K0I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYREAGVDI QAGRSFVEKI RQGVESTYRR EVLGGLGGFG GYFELPQGYQ    50
    HPVLVSGTDG VGTKLKIAQA LNQHHTIGID LVAMCVNDVL TCGAEPLFFL 100
    DYLATGKLNP QQLSDVVQGI VEGCRLSGCA LLGGETAEMP GFYPVGEYDV 150
    AGFCVGIVEK SKILDGSQVN IGDIAIGLAS SGVHSNGFSL VRKIVEVNGL 200
    NWSDRPQLLN GQTLGEVLLT PTQLYVKPIL NALNSGLDIH AMAHITGGGL 250
    PENLPRCLDK GQSVEIIDKS WNILPIFQWI AQQGQISPAS MYETFNMGIG 300
    FVVIVPPEKA QLAVNFLENQ GILAYEIGKV IEGKGEVVIE SND 343
    Length:343
    Mass (Da):36,758
    Last modified:February 10, 2009 - v1
    Checksum:i4ABD4A2ADB109705
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001287 Genomic DNA. Translation: ACK67464.1.
    RefSeqiWP_012596723.1. NC_011726.1.
    YP_002373620.1. NC_011726.1.

    Genome annotation databases

    EnsemblBacteriaiACK67464; ACK67464; PCC8801_3499.
    GeneIDi7102610.
    KEGGicyp:PCC8801_3499.
    PATRICi21579363. VBICyaSp125535_3686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001287 Genomic DNA. Translation: ACK67464.1 .
    RefSeqi WP_012596723.1. NC_011726.1.
    YP_002373620.1. NC_011726.1.

    3D structure databases

    ProteinModelPortali B7K0I0.
    SMRi B7K0I0. Positions 11-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41431.PCC8801_3499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK67464 ; ACK67464 ; PCC8801_3499 .
    GeneIDi 7102610.
    KEGGi cyp:PCC8801_3499.
    PATRICi 21579363. VBICyaSp125535_3686.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci CSP41431:GHLK-3540-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 8801.

    Entry informationi

    Entry nameiPUR5_CYAP8
    AccessioniPrimary (citable) accession number: B7K0I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3