SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7K0C3

- B7K0C3_CYAP8

UniProt

B7K0C3 - B7K0C3_CYAP8

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Riboflavin biosynthesis protein RibBA
Gene
ribBA, PCC8801_3439
Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity.UniRule annotation
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity.UniRule annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation
GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations
Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi36 – 361Magnesium or manganese 2 By similarityUniRule annotation
Binding sitei40 – 401D-ribulose 5-phosphate By similarityUniRule annotation
Sitei136 – 1361Essential for DHBP synthase activity By similarityUniRule annotation
Metal bindingi153 – 1531Magnesium or manganese 2 By similarityUniRule annotation
Binding sitei174 – 1741D-ribulose 5-phosphate By similarityUniRule annotation
Sitei174 – 1741Essential for DHBP synthase activity By similarityUniRule annotation
Metal bindingi269 – 2691Zinc; catalytic By similarityUniRule annotation
Metal bindingi280 – 2801Zinc; catalytic By similarityUniRule annotation
Metal bindingi282 – 2821Zinc; catalytic By similarityUniRule annotation
Binding sitei285 – 2851GTP By similarityUniRule annotation
Binding sitei329 – 3291GTP By similarityUniRule annotation
Active sitei341 – 3411Proton acceptor; for GTP cyclohydrolase activity By similarityUniRule annotation
Active sitei343 – 3431Nucleophile; for GTP cyclohydrolase activity By similarityUniRule annotation
Binding sitei364 – 3641GTP By similarityUniRule annotation
Binding sitei369 – 3691GTP By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2685GTP By similarityUniRule annotation
Nucleotide bindingi307 – 3093GTP By similarityUniRule annotation

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. manganese ion binding Source: UniProtKB-HAMAP
  6. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, LyaseUniRule annotation

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSP41431:GHLK-3480-MONOMER.
UniPathwayiUPA00275; UER00399.
UPA00275; UER00400.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis protein RibBAUniRule annotation
Gene namesi
Name:ribBAUniRule annotation
Ordered Locus Names:PCC8801_3439Imported
OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))Imported
Taxonomic identifieri41431 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000008204: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi41431.PCC8801_3439.

Structurei

3D structure databases

ProteinModelPortaliB7K0C3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 211211DHBP synthase By similarityUniRule annotation
Add
BLAST
Regioni35 – 362D-ribulose 5-phosphate binding By similarityUniRule annotation
Regioni150 – 1545D-ribulose 5-phosphate binding By similarityUniRule annotation
Regioni212 – 556345GTP cyclohydrolase II By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the GTP cyclohydrolase II family.UniRule annotation
In the N-terminal section; belongs to the DHBP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0108.
HOGENOMiHOG000115440.
KOiK14652.
OMAiGKGLICM.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00179. RibA.
MF_00180. RibB.
MF_01283. RibBA.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR000926. GTP_CycHdrlaseII_RibA.
IPR016299. Riboflavin_synth_RibBA.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00505. ribA. 1 hit.
TIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

B7K0C3-1 [UniParc]FASTAAdd to Basket

« Hide

MDASPNAIAQ FDTIDAALAD IKAGKAIIVV DDENRENEGD LICAAQFATP    50
NMINFMAVEA RGLICLAMMG ERLDTLDLPL MVTKNTDSNQ TAFTVSIDAA 100
KHLGVSTGIS AEDRARTIQV AINPDTHPDD LTRPGHIFPI RAKEGGVLKR 150
AGHTEAAVDL SRLAGLYPAG VICEIQNPDG SMARLPELFE YAKKHELKLI 200
SIADLISYRL KHDRFVYRET VCQFPSQFGT FQLYAYRNVL DGTEHVAIVK 250
GDPAQFKDQP VMVRMHSECL TGDALGSMRC DCRMQLQTAL KMIEGSGLGV 300
VVYLRQEGRG IGLVNKLKAY SLQDMGLDTV EANERLGFPA DLRDYGMGAQ 350
MLNDLGVKQI RLITNNPRKI AGLKGYGLEV VDRVPLLIEA NDYNANYLAT 400
KAEKLGHLLL HTYLITVAID WETEMRSAKE RYGNLEKLRQ LCRSSQLLLQ 450
EEVRPIANAL FSSPSLIFHL GFEQGKMVDP HWYHNSKHPY LSAIAQILDE 500
IVTWPNIKRL EFLISSGDDP LLGLQVQLDR HTFSLKDQPS EYLRELEMQT 550
IYSFQG 556
Length:556
Mass (Da):61,992
Last modified:February 10, 2009 - v1
Checksum:iABDD8DBF8EF3DE98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67407.1.
RefSeqiYP_002373563.1. NC_011726.1.

Genome annotation databases

EnsemblBacteriaiACK67407; ACK67407; PCC8801_3439.
GeneIDi7103129.
KEGGicyp:PCC8801_3439.
PATRICi21579233. VBICyaSp125535_3621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67407.1 .
RefSeqi YP_002373563.1. NC_011726.1.

3D structure databases

ProteinModelPortali B7K0C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41431.PCC8801_3439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK67407 ; ACK67407 ; PCC8801_3439 .
GeneIDi 7103129.
KEGGi cyp:PCC8801_3439.
PATRICi 21579233. VBICyaSp125535_3621.

Phylogenomic databases

eggNOGi COG0108.
HOGENOMi HOG000115440.
KOi K14652.
OMAi GKGLICM.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
UPA00275 ; UER00400 .
BioCyci CSP41431:GHLK-3480-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00179. RibA.
MF_00180. RibB.
MF_01283. RibBA.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR000926. GTP_CycHdrlaseII_RibA.
IPR016299. Riboflavin_synth_RibBA.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00505. ribA. 1 hit.
TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8801.

Entry informationi

Entry nameiB7K0C3_CYAP8
AccessioniPrimary (citable) accession number: B7K0C3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotation

External Data

Dasty 3

Similar proteinsi