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B7JYL8

- B7JYL8_CYAP8

UniProt

B7JYL8 - B7JYL8_CYAP8

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciCSP41431:GHLK-812-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:PCC8801_0806Imported
    OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))Imported
    Taxonomic identifieri41431 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000008204: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi41431.PCC8801_0806.

    Structurei

    3D structure databases

    ProteinModelPortaliB7JYL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7JYL8-1 [UniParc]FASTAAdd to Basket

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    MNDRSTTTIQ VIGGGLAGTE AAWQIAQAGV PVILYEMRPL RTSPAHHSEE    50
    LAELVCSNSF GAMSSDRAAG LLHEELRRLG SIIIQTADQH SVPAGGALAV 100
    DRGVFSHALT QTLDNHPLIT LKRAAIGQIP SEGIVVLTTG PLTTPDLAED 150
    LQRFTGMDYL SFFDAASPII VGDSINRDIA FLASRYDKGE AAYLNCPLTK 200
    EQYLHFREEL CQAEQAELKD FERETAQFFE GCLPIEELAK RGEDTMRYGP 250
    LKPVGLFDSR LGDFRDPENK GKRPYGVVQL RQEDKNGQLW NMVGFQTNLK 300
    WGEQKRIFRL IPGLETAEFV RMGVMHRNTF INSPQLLEAT LQFKSRPTLL 350
    AAGQLIGTEG YSAAAAGGWL AGTNAARLAL RLDPLKMPET TMMGALFEFI 400
    SSASPKHFQP MPPNFGIIPE LSHKIGNKRE RYGKYRDRAL ADLETWNNQS 450
    VNKRSLCVQ 459
    Length:459
    Mass (Da):50,805
    Last modified:February 10, 2009 - v1
    Checksum:i072BE7030E92E378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001287 Genomic DNA. Translation: ACK64888.1.
    RefSeqiYP_002371044.1. NC_011726.1.

    Genome annotation databases

    EnsemblBacteriaiACK64888; ACK64888; PCC8801_0806.
    GeneIDi7103150.
    KEGGicyp:PCC8801_0806.
    PATRICi21573822. VBICyaSp125535_0949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001287 Genomic DNA. Translation: ACK64888.1 .
    RefSeqi YP_002371044.1. NC_011726.1.

    3D structure databases

    ProteinModelPortali B7JYL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 41431.PCC8801_0806.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK64888 ; ACK64888 ; PCC8801_0806 .
    GeneIDi 7103150.
    KEGGi cyp:PCC8801_0806.
    PATRICi 21573822. VBICyaSp125535_0949.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci CSP41431:GHLK-812-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 8801Imported.

    Entry informationi

    Entry nameiB7JYL8_CYAP8
    AccessioniPrimary (citable) accession number: B7JYL8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3