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B7JYL8

- B7JYL8_CYAP8

UniProt

B7JYL8 - B7JYL8_CYAP8

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene
trmFO, PCC8801_0806
Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotationSAAS annotations

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotations

Cofactori

FAD By similarity.UniRule annotationSAAS annotations

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186FAD By similarityUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

FADUniRule annotationSAAS annotations, Flavoprotein

Enzyme and pathway databases

BioCyciCSP41431:GHLK-812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:PCC8801_0806Imported
OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))Imported
Taxonomic identifieri41431 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000008204: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi41431.PCC8801_0806.

Structurei

3D structure databases

ProteinModelPortaliB7JYL8.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7JYL8-1 [UniParc]FASTAAdd to Basket

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MNDRSTTTIQ VIGGGLAGTE AAWQIAQAGV PVILYEMRPL RTSPAHHSEE    50
LAELVCSNSF GAMSSDRAAG LLHEELRRLG SIIIQTADQH SVPAGGALAV 100
DRGVFSHALT QTLDNHPLIT LKRAAIGQIP SEGIVVLTTG PLTTPDLAED 150
LQRFTGMDYL SFFDAASPII VGDSINRDIA FLASRYDKGE AAYLNCPLTK 200
EQYLHFREEL CQAEQAELKD FERETAQFFE GCLPIEELAK RGEDTMRYGP 250
LKPVGLFDSR LGDFRDPENK GKRPYGVVQL RQEDKNGQLW NMVGFQTNLK 300
WGEQKRIFRL IPGLETAEFV RMGVMHRNTF INSPQLLEAT LQFKSRPTLL 350
AAGQLIGTEG YSAAAAGGWL AGTNAARLAL RLDPLKMPET TMMGALFEFI 400
SSASPKHFQP MPPNFGIIPE LSHKIGNKRE RYGKYRDRAL ADLETWNNQS 450
VNKRSLCVQ 459
Length:459
Mass (Da):50,805
Last modified:February 10, 2009 - v1
Checksum:i072BE7030E92E378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK64888.1.
RefSeqiYP_002371044.1. NC_011726.1.

Genome annotation databases

EnsemblBacteriaiACK64888; ACK64888; PCC8801_0806.
GeneIDi7103150.
KEGGicyp:PCC8801_0806.
PATRICi21573822. VBICyaSp125535_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK64888.1 .
RefSeqi YP_002371044.1. NC_011726.1.

3D structure databases

ProteinModelPortali B7JYL8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41431.PCC8801_0806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK64888 ; ACK64888 ; PCC8801_0806 .
GeneIDi 7103150.
KEGGi cyp:PCC8801_0806.
PATRICi 21573822. VBICyaSp125535_0949.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci CSP41431:GHLK-812-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8801.

Entry informationi

Entry nameiB7JYL8_CYAP8
AccessioniPrimary (citable) accession number: B7JYL8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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