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B7JYA9

- SYL_CYAP8

UniProt

B7JYA9 - SYL_CYAP8

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP41431:GHLK-3275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PCC8801_3236
OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Taxonomic identifieri41431 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000008204: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Leucine--tRNA ligasePRO_1000199191Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi41431.PCC8801_3236.

Structurei

3D structure databases

ProteinModelPortaliB7JYA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi617 – 6215"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7JYA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESQYNAAAI EQKWQQDWVK QGLDKTPENS NKPKFYALSM FPYPSGNLHM
60 70 80 90 100
GHVRNYVITD VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRGIPPAEW
110 120 130 140 150
TYKNMSQMKQ QLQTLGLSID WEREVATCAP EYYKWTQWLF LQLYQAGLAY
160 170 180 190 200
QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS GAKVERKLLR QWFLKITDYA
210 220 230 240 250
EQLLTDLDKL PGWPDRVKLM QENWIGKSVG AYLEFPIKGS EEKIAVFTTR
260 270 280 290 300
PDTVYGVTYV VLAPEHPLTL KVTTPEQKAA VDAFIEEVSN ESEIERTAED
310 320 330 340 350
KPKRGILTGG TAINPFNGQE IPILIADYVL YEYGTGAVMG VPAHDTRDFK
360 370 380 390 400
FAKEKQLPIK VVIIPENSDN TNPPLTEAYT DPGIMVNSGI FDGIQSTEGK
410 420 430 440 450
TAIIEYAEKE GYGKARIQYR LRDWLISRQR YWGCPIPVVH CPSCGTVAVP
460 470 480 490 500
DADLPVKLPE NVEFTGRDAS PLAKLEDWIN VPCPSCGEPA KRETDTMDTF
510 520 530 540 550
IDSSWYYLRY TDANNNQEAF NLEKANDWMA IDQYVGGIEH AILHLLYSRF
560 570 580 590 600
FTKALRDRGL VNIDEPFKRL LTQGMVQGLT YKNPQTGKYV PSENVIFQDD
610 620 630 640 650
HYRDKETGEI LSFFYEKMSK SKYNGVDPKQ VLGKYGADTA RMFILFKAPP
660 670 680 690 700
EKDLEWDDAD VEGQFRFLNR VWRLVANYLE NKPKTVKKAS ELTKEDKDLR
710 720 730 740 750
RAIHTAIKEI SEDLEGDYQF NTAVSELMKL SNALTDAKCL ESGVYQEGIE
760 770 780 790 800
TLLILLAPFA PHIAEELWHN LGYEKSIHLQ SWPTVNPDAL VVDEITLVIQ
810 820 830 840 850
IMGKTRGTIQ VSATATKDEL EKLARESEVG QRYLDGQDVK KVIVVPGKLV

NFVIAK
Length:856
Mass (Da):97,318
Last modified:February 10, 2009 - v1
Checksum:iC5B2469C542BE1FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67211.1.
RefSeqiWP_012596472.1. NC_011726.1.
YP_002373367.1. NC_011726.1.

Genome annotation databases

EnsemblBacteriaiACK67211; ACK67211; PCC8801_3236.
GeneIDi7105365.
KEGGicyp:PCC8801_3236.
PATRICi21578831. VBICyaSp125535_3421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67211.1 .
RefSeqi WP_012596472.1. NC_011726.1.
YP_002373367.1. NC_011726.1.

3D structure databases

ProteinModelPortali B7JYA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41431.PCC8801_3236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK67211 ; ACK67211 ; PCC8801_3236 .
GeneIDi 7105365.
KEGGi cyp:PCC8801_3236.
PATRICi 21578831. VBICyaSp125535_3421.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP41431:GHLK-3275-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8801.

Entry informationi

Entry nameiSYL_CYAP8
AccessioniPrimary (citable) accession number: B7JYA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3