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B7JYA9

- SYL_CYAP8

UniProt

B7JYA9 - SYL_CYAP8

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Protein
Leucine--tRNA ligase
Gene
leuS, PCC8801_3236
Organism
Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP41431:GHLK-3275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PCC8801_3236
OrganismiCyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1))
Taxonomic identifieri41431 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000008204: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Leucine--tRNA ligaseUniRule annotation
PRO_1000199191Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi41431.PCC8801_3236.

Structurei

3D structure databases

ProteinModelPortaliB7JYA9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi617 – 6215"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7JYA9-1 [UniParc]FASTAAdd to Basket

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MESQYNAAAI EQKWQQDWVK QGLDKTPENS NKPKFYALSM FPYPSGNLHM    50
GHVRNYVITD VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRGIPPAEW 100
TYKNMSQMKQ QLQTLGLSID WEREVATCAP EYYKWTQWLF LQLYQAGLAY 150
QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS GAKVERKLLR QWFLKITDYA 200
EQLLTDLDKL PGWPDRVKLM QENWIGKSVG AYLEFPIKGS EEKIAVFTTR 250
PDTVYGVTYV VLAPEHPLTL KVTTPEQKAA VDAFIEEVSN ESEIERTAED 300
KPKRGILTGG TAINPFNGQE IPILIADYVL YEYGTGAVMG VPAHDTRDFK 350
FAKEKQLPIK VVIIPENSDN TNPPLTEAYT DPGIMVNSGI FDGIQSTEGK 400
TAIIEYAEKE GYGKARIQYR LRDWLISRQR YWGCPIPVVH CPSCGTVAVP 450
DADLPVKLPE NVEFTGRDAS PLAKLEDWIN VPCPSCGEPA KRETDTMDTF 500
IDSSWYYLRY TDANNNQEAF NLEKANDWMA IDQYVGGIEH AILHLLYSRF 550
FTKALRDRGL VNIDEPFKRL LTQGMVQGLT YKNPQTGKYV PSENVIFQDD 600
HYRDKETGEI LSFFYEKMSK SKYNGVDPKQ VLGKYGADTA RMFILFKAPP 650
EKDLEWDDAD VEGQFRFLNR VWRLVANYLE NKPKTVKKAS ELTKEDKDLR 700
RAIHTAIKEI SEDLEGDYQF NTAVSELMKL SNALTDAKCL ESGVYQEGIE 750
TLLILLAPFA PHIAEELWHN LGYEKSIHLQ SWPTVNPDAL VVDEITLVIQ 800
IMGKTRGTIQ VSATATKDEL EKLARESEVG QRYLDGQDVK KVIVVPGKLV 850
NFVIAK 856
Length:856
Mass (Da):97,318
Last modified:February 10, 2009 - v1
Checksum:iC5B2469C542BE1FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67211.1.
RefSeqiWP_012596472.1. NC_011726.1.
YP_002373367.1. NC_011726.1.

Genome annotation databases

EnsemblBacteriaiACK67211; ACK67211; PCC8801_3236.
GeneIDi7105365.
KEGGicyp:PCC8801_3236.
PATRICi21578831. VBICyaSp125535_3421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001287 Genomic DNA. Translation: ACK67211.1 .
RefSeqi WP_012596472.1. NC_011726.1.
YP_002373367.1. NC_011726.1.

3D structure databases

ProteinModelPortali B7JYA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 41431.PCC8801_3236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK67211 ; ACK67211 ; PCC8801_3236 .
GeneIDi 7105365.
KEGGi cyp:PCC8801_3236.
PATRICi 21578831. VBICyaSp125535_3421.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP41431:GHLK-3275-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8801.

Entry informationi

Entry nameiSYL_CYAP8
AccessioniPrimary (citable) accession number: B7JYA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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