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B7JS05 (ARLY_BACC0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BCAH820_4747
OrganismBacillus cereus (strain AH820) [Complete proteome] [HAMAP]
Taxonomic identifier405535 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group ›

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_1000116196

Sequences

Sequence LengthMass (Da)Tools
B7JS05 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 185D599C6E35174A

FASTA46252,121
        10         20         30         40         50         60 
MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSIA HVTMLAKQGI VTKEEAEKIK 

        70         80         90        100        110        120 
IGLQYLLEEA KQNKLHFSVE AEDIHLNIEK MLIEKIGEVG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LKEKVEHIMK ATKQLQTVLV HQAENNIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 

       190        200        210        220        230        240 
NRYEDSLKRI NISPLGAGAL AGTTFPIDRE YSAELLGLNG IYENSLDAVS DRDFILEFLS 

       250        260        270        280        290        300 
NSSMLMMHLS RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT VNKEKMGQAV 

       370        380        390        400        410        420 
TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLHCTQKGI YLVDVPLATY KEMSSLFEED 

       430        440        450        460 
LYEVLSPYAA VKRRNSAGGT GFEQIEKALE KAKGLTKEAI KN

« Hide

References

[1]"Genome sequence of Bacillus cereus AH820."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AH820.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001283 Genomic DNA. Translation: ACK92244.1.
RefSeqYP_002453693.1. NC_011773.1.

3D structure databases

ProteinModelPortalB7JS05.
ModBaseSearch...

Protein-protein interaction databases

STRING405535.BCAH820_4747.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK92244; ACK92244; BCAH820_4747.
GeneID7189488.
KEGGbcu:BCAH820_4747.
PATRIC18846471. VBIBacCer122868_4740.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAKEGIFDA.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBCER405535:GHSL-5417-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BACC0
AccessionPrimary (citable) accession number: B7JS05
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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