Reviewed, UniProtKB/Swiss-Prot B7JS05 (ARLY_BACC0)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BCAH820_4747

Organism

Bacillus cereus (strain AH820) [Complete proteome] [HAMAP]

Taxonomic identifier

405535 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Argininosuccinate lyase HAMAP MF_00006		PRO_1000116196

Sequences

	Sequence		Length	Mass (Da)
	B7JS05-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 185D599C6E35174A	FASTA	462	52,121
	10 20 30 40 50 60 MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSIA HVTMLAKQGI VTKEEAEKIK 70 80 90 100 110 120 IGLQYLLEEA KQNKLHFSVE AEDIHLNIEK MLIEKIGEVG GKLHTGRSRN DQVATDMHLY 130 140 150 160 170 180 LKEKVEHIMK ATKQLQTVLV HQAENNIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 190 200 210 220 230 240 NRYEDSLKRI NISPLGAGAL AGTTFPIDRE YSAELLGLNG IYENSLDAVS DRDFILEFLS 250 260 270 280 290 300 NSSMLMMHLS RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT VNKEKMGQAV 370 380 390 400 410 420 TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLHCTQKGI YLVDVPLATY KEMSSLFEED 430 440 450 460 LYEVLSPYAA VKRRNSAGGT GFEQIEKALE KAKGLTKEAI KN

References

[1]	"Genome sequence of Bacillus cereus AH820." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001283 Genomic DNA. Translation: ACK92244.1.
RefSeq	YP_002453693.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7189488.
GenomeReviews	Gene locus BCAH820_4747 in contig CP001283_GR.
KEGG	bcu:BCAH820_4747.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BACC0

Accession

Primary (citable) accession number: B7JS05

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)