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B7JR48

- HDOX_BACC0

UniProt

B7JR48 - HDOX_BACC0

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Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus cereus (strain AH820)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61IronUniRule annotation
Sitei66 – 661Transition state stabilizerUniRule annotation
Metal bindingi76 – 761Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. heme binding Source: UniProtKB-HAMAP
  2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. heme catabolic process Source: UniProtKB-HAMAP
  2. iron assimilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBCER405535:GHSL-4669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenaseUniRule annotation (EC:1.14.99.3UniRule annotation)
Alternative name(s):
Heme oxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdGUniRule annotation
Ordered Locus Names:BCAH820_4656
OrganismiBacillus cereus (strain AH820)
Taxonomic identifieri405535 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001363: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Heme-degrading monooxygenasePRO_1000140201Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi405535.BCAH820_4656.

Structurei

3D structure databases

ProteinModelPortaliB7JR48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9493ABMUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation
Contains 1 ABM domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2329.
HOGENOMiHOG000008026.
KOiK07145.
OMAiFRESHSH.
OrthoDBiEOG6GTZMS.

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS51725. ABM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7JR48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIVTNTAKI TKGNGHKLID RFNKVGQVET MPGFLGLEVL LTQNTVDYDE
60 70 80 90 100
VTISTRWNAK EDFQGWTKSP AFKAAHSHQG GMPDYILDNK ISYYDVKVVR

MPMAAAQ
Length:107
Mass (Da):12,004
Last modified:February 10, 2009 - v1
Checksum:iACB308A337A92DFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001283 Genomic DNA. Translation: ACK91407.1.
RefSeqiYP_002453602.1. NC_011773.1.

Genome annotation databases

EnsemblBacteriaiACK91407; ACK91407; BCAH820_4656.
GeneIDi7187385.
KEGGibcu:BCAH820_4656.
PATRICi18846285. VBIBacCer122868_4647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001283 Genomic DNA. Translation: ACK91407.1 .
RefSeqi YP_002453602.1. NC_011773.1.

3D structure databases

ProteinModelPortali B7JR48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405535.BCAH820_4656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK91407 ; ACK91407 ; BCAH820_4656 .
GeneIDi 7187385.
KEGGi bcu:BCAH820_4656.
PATRICi 18846285. VBIBacCer122868_4647.

Phylogenomic databases

eggNOGi COG2329.
HOGENOMi HOG000008026.
KOi K07145.
OMAi FRESHSH.
OrthoDBi EOG6GTZMS.

Enzyme and pathway databases

BioCyci BCER405535:GHSL-4669-MONOMER.

Family and domain databases

HAMAPi MF_01272. Heme_degrading_monooxygenase.
InterProi IPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view ]
Pfami PF03992. ABM. 1 hit.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 1 hit.
PROSITEi PS51725. ABM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus AH820."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AH820.

Entry informationi

Entry nameiHDOX_BACC0
AccessioniPrimary (citable) accession number: B7JR48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3